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tag gene therapy developmental biology ecology microbiology

Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Collage of images including sperm, bacteria, coral, and an illustration of a researcher
Our Favorite Cell and Molecular Biology Stories of 2021
Jef Akst | Dec 2, 2021 | 3 min read
Beyond The Scientist’s coverage of COVID-19’s molecular underpinnings were many other stories highlighting the advances made in scientists’ understanding of the biology of cells.
Artist’s rendition of the molecular structure of a ribosome (blue and purple) as it produces a polypeptide chain (red) from an mRNA template (orange and gray), with tRNA molecules (dark purple) shuttling amino acids.
Specialized Sperm Ribosomes Are Key to Male Fertility in Mice
Dan Robitzski | Dec 15, 2022 | 4 min read
A previously unknown kind of ribosome is responsible for folding sperm proteins, which decay before fertilization if prepared by other ribosomes.
Genomic Methylation Collector
Beth Marie Mole | Oct 21, 2012 | 2 min read
A parasitic worm accumulates epigenetic DNA tags over its lifetime.  
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
The Ecology of Tumors
Paraic A. Kenny, Celeste M. Nelson, and Mina J. Bissell | Apr 1, 2006 | 10+ min read
FEATUREThe Ecology of Tumors   Courtesy of Nasa Ames Research CenterBy perturbing the microenvironment, wounds and infection may be key to tumor development.BY PARAIC A. KENNY, CELESTE M. NELSON, AND MINA J. BISSELLNo tumor is an island. Chemical and physical forces exerted by the diverse cellular populations that surround a tumor - its so-called microenvironment - shape development and progression. Manipulating these 'ecologi
Bioremediation: Cleaning Up With Biology And Technology
Angela Martello | Jan 6, 1991 | 7 min read
As the necessity of cleaning up the environment moves to the forefront of the public's consciousness, researchers in increasing numbers have been enlisting some of the earth's tiniest creatures to help clean up highly polluted sites and reclaim soils and groundwater systems. Stimulated by advances in microbiology and biotechnology, the booming multidisciplinary field of environmental biotechnology focuses on the use of microorganisms to treat or degrade hazardous waste, encompassing the techniq
Broadening Applicability Fosters Growth In Microbiology's Current Job Market
Marcia Clemmitt | May 16, 1993 | 8 min read
Life scientists are increasingly adopting the belief that microorganisms are virtually everywhere and are responsible for just about everything. This, plus the maturation of molecular- level methods of working with these tiny creatures, is a source of considerable optimism for microbiologists as the 93rd general meeting of the American Society for Microbiology (ASM) convenes in Atlanta this week. What they see, in career terms, is that progress in their field is bound to yield an ever-widening
Biological Terrorism
Jennifer Fisher Wilson | Nov 11, 2001 | 8 min read
One warning came in black-and-white in 1993: A U.S. Congressional Office of Technology Assessment report projected that releasing 100 kilograms of aerosolized anthrax spores upwind of the U.S. capital could kill between 130,000 and 3 million people-a lethality at least matching that of a hydrogen bomb. Last year, a U.S. Justice Department exercise revealed that discharging pneumonic plague in Denver could create 3,700 or more cases, with an estimated 950 or more deaths within a week.1 Then, acco

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