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image: Anti-CRISPR Protein Reduces Off-Target Effects

Anti-CRISPR Protein Reduces Off-Target Effects

By | July 12, 2017

AcrIIA4, an inhibitor protein from the Listeria bacteriophage, can block DNA from binding to Cas9 during genome editing.

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image: Was a Drop in CRISPR Firms’ Stock Warranted?

Was a Drop in CRISPR Firms’ Stock Warranted?

By | June 7, 2017

A study of off-target effects that sparked fear among investors of genome-editing companies receives methodological criticisms.

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Sangamo Therapeutics will use zinc finger nucleases to introduce the gene for a missing clotting factor into the livers of men with hemophilia B.

1 Comment

image: Speaking of Science Policy

Speaking of Science Policy

By | February 21, 2017

Notable quotes from the American Association for the Advancement of Science annual meeting

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An international committee says scientists should be allowed to modify human embryos as long as strict oversight criteria are met. 

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image: ACMG Urges Caution When Editing Embryo Genomes

ACMG Urges Caution When Editing Embryo Genomes

By | January 30, 2017

The American College of Medical Genetics and Genomics calls on scientists and health care providers to engage in public discussion about the ethical issues involved in genome editing. 

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image: More Anti-CRISPR Proteins to Block Cas9

More Anti-CRISPR Proteins to Block Cas9

By | December 29, 2016

The latest CRISPR deactivators to be discovered turn off the Streptococcus pyogenes Cas9 widely used in genome editing.

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image: New CRISPR-Cas Enzymes Discovered

New CRISPR-Cas Enzymes Discovered

By | December 22, 2016

A metagenomics analysis finds Cas9 in archaea for the first time, along with two previously unknown Cas nucleases from bacteria.

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image: Self-Editing Genetic Barcodes

Self-Editing Genetic Barcodes

By | December 14, 2016

Scientists create a CRISPR-based, self-editing cellular–barcoding system for extensive molecular recording.

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image: Book Excerpt from <em>Redesigning Life</em>

Book Excerpt from Redesigning Life

By | December 1, 2016

In Chapter 8, author John Parrington explores the intersection of precision genome editing and stem cell technologies.

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