Karen Pallarito | Oct 24, 2004 | 9 min read
PINNING THE BLAME:© 2004 New England Journal of MedicineCurrent and emerging Alzheimer Disease treatment options hinge on the hypothesis that amyloid β (Aβ), created by the sequential cleavage of amyloid precursor protein (APP), is the culprit behind neurodegeneration and associated cognitive and behavioral abnormalities. This could occur through multiple pathways. (Reprinted with permission from N Engl J Med, 351:56, 2004.)Neuroscience has made impressive strides since 1936 Nobel