The Scientist Staff | Mar 15, 1992 | 2 min read
B.F. Pugh, R. Tjian, "Mechanism of transcriptional activation by Sp1: evidence for coactivators," Cell, 61:1187-97, 1990. Franklin Pugh (Howard Hughes Medical Institute, University of California, Berkeley): "The story of eukaryotic transcriptional coactivators has provoked a new way of thinking about how sequence-specific activators communicate with the basal transcriptional machinery. "The prevailing thought prior to this work was that the TFIID component of this machine was a single protein