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tag chaperone mediated autophagy cell molecular biology neuroscience culture

Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
Waste-Management Consultant
Megan Scudellari | Nov 1, 2013 | 9 min read
By audaciously pursuing an abandoned area of research, Ana María Cuervo discovered how cells selectively break down their waste, and revealed the health consequences when that process malfunctions.
Longevity
Jill Adams(juadams@the-scientist.com) | May 8, 2005 | 7 min read
During autophagy-literally "self-eating"-cells deliver cytoplasmic constituents, including whole organelles, to the lysosome for degradation.
The Genes of Parkinson’s Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011 | 10 min read
The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.
Getting Drugs Past the Blood-Brain Barrier
Amanda B. Keener | Nov 1, 2017 | 10+ min read
To treat neurological disease, researchers develop techniques to bypass or trick the guardian of the central nervous system.
Antibody Alternatives
Paul Ko Ferrigno and Jane McLeod | Feb 1, 2016 | 10+ min read
Nucleic acid aptamers and protein scaffolds could change the way researchers study biological processes and treat disease.
Top 10 Innovations 2013
The Scientist | Dec 1, 2013 | 10+ min read
The Scientist’s annual competition uncovered a bonanza of interesting technologies that made their way onto the market and into labs this year.
On the Chain Gang
Keith D. Wilkinson and David Fushman | Jul 1, 2012 | 10 min read
More than simply helping haul out a cell’s garbage, ubiquitin, with its panoply of chain lengths and shapes, marks and regulates many unrelated cellular processes.
The Orange and the Circus Tent
Ari Helenius | Oct 1, 2008 | 9 min read
The Orange and the Circus Tent Illustrations by Grady McFerrin What viruses teach us about the workings of mammalian cells. By Ari Helenius Article Extras 1 In those days, my interest was largely biochemical, particularly in the properties of membrane proteins, although I did also spend a lot of time trying to take the virus apart to its individual components, in an attempt to recreate the infectious particle from scratch. Needless to sa

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