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tag circadian clocks developmental biology genetics genomics

A Nile rat sitting atop fruits
Genome Spotlight: Nile Rat (Avicanthis niloticus)
Christie Wilcox, PhD | Nov 23, 2022 | 4 min read
A reference sequence for this emerging model organism will facilitate research on type 2 diabetes and the health effects of circadian rhythm disruption.
Circadian Rhythm Homology and Divergence
Eugene Russo | Jul 9, 2000 | 7 min read
Courtesy of ScienceThe fruit fly circadian cycle shares three strong similarities with the mammalian: the per gene itself, CLOCK and BMAL regulation of per, and a gene called tau in hamsters and double-time (dbt) in flies, both of which encode the enzyme CKI*. Molecular biologists have been teasing apart the intricate innards of organisms' biological clocks for decades, gaining rare insight into a veritable bridge between genes and behavior. Those clocks' circadian rhythms, the 24-hour cycles t
Circadian Clock Genes Help a Crop Pest Adapt to Climate Change
Emily Makowski | Jan 13, 2020 | 3 min read
As global temperatures rise and winters shorten, caterpillars of the corn borer moth are emerging earlier in parts of the US thanks to changes in two genes, researchers find.
Circadian Rhythms
Eugene Russo | Oct 24, 1999 | 4 min read
D.P. King, Y.L. Zhao, A.M. Sangoram, L.D. Wilsbacher, M. Tanaka, M.P. Antoch, T.D.L. Steeves, M.H. Vitaterna, J.M. Kornhauser, P.L. Lowrey, F.W. Turek, J.S. Takahashi, "Positional cloning of the mouse circadian Clock gene," Cell, 89:641-53, May 16, 1997. (Cited in more than 160 papers since publication) Comments by Joseph S. Takahashi, a Howard Hughes Medical Institute investigator and professor of neurobiology and physiology at Northwestern University This paper proved to be as significant for
Keeping Time with Drosophila
Laura Bonetta | Feb 3, 2002 | 10 min read
Circadian clocks—the biological timekeepers that operate on a daily cycle—keep virtually every living creature in tune with its environment. These internal clocks regulate a wide range of fundamental biological processes, including movement, smell, sleep, mating, and feeding. A true circadian clock is endogenous; that is, it keeps time even in the absence of external cues. The clock can, however, be reset, or entrained, by daylight, allowing the synchronization of circadian rhythms t
Muscle Clocks Play a Role in Regulating Metabolism
Diana Kwon | Sep 1, 2018 | 9 min read
Just 20 years ago, scientists didn’t even realize muscles had their own circadian clocks. Now they are beginning to appreciate their importance in health. 
High-Throughput Technology Tackles Circadian Rhythms
Karen Kreeger | Nov 16, 2003 | 7 min read
Like watchmakers, biologists have hunkered down over their respective model organisms, meticulously seeking out biological timekeepers, the genes important for regulating life's internal clock. Up until now, classical approaches had not uncovered the finest details of the machinery that synchronizes life processes with light and darkness, let alone how these rhythms affect behavior and metabolism. "[They] haven't identified genes other than the main components such as the central transcriptio
Top 7 in Genomics & Genetics
Sabrina Richards | Sep 19, 2011 | 3 min read
A snapshot of the most highly ranked articles in genomics, genetics and related areas, from Faculty of 1000
Circadian Rhythms Influence Treatment Effects
Jyoti Madhusoodanan | Apr 1, 2017 | 10+ min read
Across many diseases, taking medication at specific times of day may make the therapy more effective.
Advances in the functional characterization of newly discovered microproteins hint at their diverse roles  in health and disease
The Dark Matter of the Human Proteome
Annie Rathore | Apr 1, 2019 | 10 min read
Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.

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