Credit: courtesy of John Sulston" /> Credit: courtesy of John Sulston Starting in 1980, John Sulston spent 18 months hunched over a microscope watching Caenorhabditis elegans embryos divide. Together with Bob Horvitz at the Laboratory of Molecular Biology in Cambridge, England, he had already mapped the fate of every cell in the adult worm from the moment the egg hatched, but the embryonic cell line

Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.

The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.

Researchers developed a “test tube” so tiny that it can hold a single cell. These vials enabled them to connect protein secretion levels with surface markers and transcriptome data from the same cell. 

A. Kazlauskas, C. Ellis, T. Pawson, J.A. Cooper, "Binding of GAP to activated PDGF receptors," Science, 247:1578-81, 1990. Andrius Kazlauskas (National Jewish Center for Immunology and Respiratory Medicine, Denver): "The GTPase activator protein of ras (GAP) is one of a number of recently discovered proteins that appear to maintain nucleotide binding proteins such as ras in an inactive state, that is, coupled with GDP instead of GTP. Since regulation of GAP activity could affect cellular leve

The road to developing monoclonal antibodies for effectively targeting cancer was paved with tenacity, passion, and strokes of luck.

Scientists around the world investigate how bat immune systems cope with viral attacks and how this information could be used to keep humans safe.

Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.

A recent paper challenges earlier findings that germline factors expressed in normal body cells influence life span in C. elegans.

K.C. Garcia, M. Degano, R.L. Stanfield, A. Brunmark, M.R. Jackson, P.A. Peterson, L. Teyton, I.A. Wilson, "An alpha-ß T cell receptor structure at 2.5Å and its orientation in the TCR-MHC complex," Science, 274:209-19, 1996. (Cited in more than 240 papers since publication) Comments by Ian A. Wilson, professor of molecular biology at The Scripps Research Institute in La Jolla, Calif. D.N. Garboczi, P. Ghosh, U. Utz, Q.R. Fan, W.E. Biddison, D.C. Wiley, "Structure of the complex bet