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image: Most Accurate CRISPR Gene Editing Yet

Most Accurate CRISPR Gene Editing Yet

By | September 22, 2017

A tweaked Cas9 nuclease reduces off-target effects to levels below that of previous versions of the enzyme.

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image: Jumping Genes Inactivated with CRISPR in Pigs

Jumping Genes Inactivated with CRISPR in Pigs

By | August 10, 2017

The study could pave the way for transplanting porcine organs to humans without the risk of reigniting endogenous retroviruses.

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image: CRISPR Corrects RNA-based Disease Defects

CRISPR Corrects RNA-based Disease Defects

By | August 10, 2017

In human cells, researchers deploy the genome editor to snip out toxic repetitive sequences.

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image: First In Vivo Function Found for Animal Circular RNA

First In Vivo Function Found for Animal Circular RNA

By | August 10, 2017

Mice lacking the RNA had deregulated microRNAs in the brain, disrupted synaptic communication, and behavioral abnormalities associated with neuropsychiatric disorders.

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image: The Cancer Genes Needed for Immunotherapy Response

The Cancer Genes Needed for Immunotherapy Response

By | August 7, 2017

Using a large CRISPR-based screen, researchers find possible genetic culprits for patients not having success with immune checkpoint inhibitors.  

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image: Resistance to HIV Engineered Via CRISPR

Resistance to HIV Engineered Via CRISPR

By | August 3, 2017

Mice transplanted with human hematopoietic stem cells that have an HIV receptor gene, CCR5, disrupted by gene editing allows the animals to ward off HIV infection. 

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image: Scientists Destroy Entire Chromosome with CRISPR

Scientists Destroy Entire Chromosome with CRISPR

By | August 1, 2017

Multiple DNA breaks at either the centromere or the long arm of the mouse Y chromosome cause it to fragment and disappear.

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image: Human Genetic Variation May Complicate CRISPR

Human Genetic Variation May Complicate CRISPR

By | July 31, 2017

Slight sequence differences confound target sites in precision genome-editing, a study shows.

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image: Anti-CRISPR Protein Reduces Off-Target Effects

Anti-CRISPR Protein Reduces Off-Target Effects

By | July 12, 2017

AcrIIA4, an inhibitor protein from the Listeria bacteriophage, can block DNA from binding to Cas9 during genome editing.

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image: Major CRISPR Patent-Holders Agree to Patent Pool

Major CRISPR Patent-Holders Agree to Patent Pool

By | July 10, 2017

The Broad Institute and others sign on to participate in a platform designed to streamline the licensing process. 

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