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image: RNAi’s Future in Drug-Target Screening

RNAi’s Future in Drug-Target Screening

By | April 17, 2017

A recent CRISPR study contradicted years of RNA interference research on a well-studied cancer drug target. But is it the last nail in the coffin for RNAi as a screening tool? 

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image: Nearly 500 lncRNAs Needed For Cell Growth Identified

Nearly 500 lncRNAs Needed For Cell Growth Identified

By | December 15, 2016

Using a modified CRISPR approach, scientists shed light on the diversity and function of 499 long noncoding RNAs.

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image: Targeting the Noncoding Genome with CRISPR

Targeting the Noncoding Genome with CRISPR

By | September 29, 2016

Two independent groups demonstrate the utility of CRISPR-based techniques to identify regulatory elements that govern disease-linked genes. 

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Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.

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image: RNA-Targeting CRISPR

RNA-Targeting CRISPR

By | June 2, 2016

Scientists identify a novel CRISPR system that zeroes in on single-stranded RNA.  

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image: Screening  with CRISPR

Screening with CRISPR

By | June 1, 2016

Ever-improving CRISPR-based tools are already ripe for large-scale genetic screens.

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image: CRISPRi-Controlled Gene Expression

CRISPRi-Controlled Gene Expression

By | March 10, 2016

A variation of the gene-editing technique can more precisely and efficiently downregulate the expression of target genes than traditional CRISPR/Cas9.

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image: Dial It Up, Dial It Down

Dial It Up, Dial It Down

By | March 1, 2016

Newer CRISPR tools for manipulating transcription will help unlock noncoding RNA’s many roles.

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image: A CRISPR Fore-Cas-t

A CRISPR Fore-Cas-t

By | March 1, 2014

A newcomer’s guide to the hottest gene-editing tool on the block

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