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Over-the-Counter Antihistamines Could Help Against Cancer
The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.
Over-the-Counter Antihistamines Could Help Against Cancer
Over-the-Counter Antihistamines Could Help Against Cancer

The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.

The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.

cancer immunotherapy

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Training Immune Cells to Be Cancer Killers
Aparna Nathan, PhD | Nov 12, 2021 | 4 min read
A career-altering experience as a cancer patient motivated one researcher to design more potent immunotherapies.
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Can mRNA Vaccine Momentum Propel Tumor Immunotherapies?
Aparna Nathan, PhD | Nov 12, 2021 | 4 min read
A guide to mRNA-based cancer vaccines and where they’re headed next
The Scientist's LabTalk Podcast - Episode 1
The Scientist | 1 min read
Myeloid Cells in Cancer and Science Advocacy: A Conversation with Dr. Miriam Merad
brain scan showing uptake of tratuzumab into tumor (arrow)
Sound Waves Aid Brain Tumor Treatment
Ruth Williams | Oct 13, 2021 | 3 min read
In a small clinical study, focusing ultrasound beams on tumors in patients’ brains helped open the blood-brain barrier to facilitate drug delivery.
CAR Macrophages Tackle Challenges in Solid Cancer Treatment
Amanda Heidt | Mar 26, 2021 | 6 min read
Following on the success of CAR T cells used to treat cancers of the blood, researchers have launched a Phase 1 clinical trial of genetically modified macrophages to target solid tumors.
Adoptive Cell Therapy Summit
The Scientist | 2 min read
Join us to learn about adoptive cell therapies from leading experts in the field of cancer immunology. 
an illustration of a mix of different bacteria
Fecal Transplant Could Boost Immunotherapy to Treat Melanoma
Shawna Williams | Feb 12, 2021 | 4 min read
The results from two Phase 1 trials bolster the case that the gut microbiome plays a role in response to the drugs.
CAR T cells, oncolytic virus, CD19, mouse model, solid cancer, liquid cancer, tumor, immune response, immunotherapy, T cell, treatment
Immunotherapy Combo Reduces Solid Tumors in Mice
Amanda Heidt | Sep 9, 2020 | 5 min read
When tumor cells are infected with an oncolytic virus carrying a modified CD19 gene, they become targets for CAR T cells engineered to recognize this molecular marker.
Contributors
The Scientist | Jul 13, 2020 | 3 min read
Meet some of the people featured in the July/August 2020 issue of The Scientist.
Harnessing Stem Cell–Like T Cells to Better Fight Cancer
Daniel E. Speiser and Werner Held | Jul 13, 2020 | 9 min read
Better understanding the CD8+ T cells already present in tumors could be key to making immunotherapies work for more patients.
Natural Killer Cell Therapies Catch Up to CAR T
Bianca Nogrady | Apr 1, 2020 | 8 min read
There’s a new cell-based cancer immunotherapy on the block.
Flu Shot Ignites Immune Attack Against Cancer in Mice
Ashley Yeager | Apr 1, 2020 | 5 min read
Injecting the seasonal flu vaccine directly into clumps of malignant cells recruits immune cells to confront the cancer.
Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice
Catherine Offord | Jan 24, 2020 | 4 min read
This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.
Immunology Leader Vincenzo Cerundolo Dies
Ashley Yeager | Jan 16, 2020 | 2 min read
The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.
Does the Microbiome Help the Body Fight Cancer?
Catherine Offord | Jul 10, 2019 | 4 min read
Research in mice and humans is beginning to establish a link between the composition of microbes in the gut and immune responses to tumor cells, but the mechanisms are not yet clear.
an illustration of T cells attacking a cancer cell
Two Patients Treated with CRISPRed Cells in Immunotherapy Trial
Shawna Williams | Apr 16, 2019 | 1 min read
One person with multiple myeloma and one with sarcoma are the first so far to receive the genetically engineered T cells in the study.
 immunotherapy  treatment may cause latent infections of Mycobacterium tuberculosis to flare up in cancer patients
Tuberculosis Can Emerge After Cancer Immunotherapy
Ashley Yeager | Apr 1, 2019 | 4 min read
At least a handful of patients have developed active TB after receiving cancer treatment designed to boost the immune system’s antitumor response.
CAR Ts solid tumor
The Next Frontier of CAR T-Cell Therapy: Solid Tumors
Kerry Grens | Apr 1, 2019 | 10+ min read
The technology has wowed the field by all but obliterating some patients’ blood cancers, but solid malignancies present new challenges.
car t cell infographic april 2019 the scientist solid tumor liquid cancer
Infographic: CAR-T Cells in Solid Versus Liquid Cancers
Kerry Grens | Apr 1, 2019 | 2 min read
Tumor accessibility, heterogeneity, and microenvironment vary between the two classes of malignancies.
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