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tag phosphatidylinositol pi 3 kinase neuroscience

Cell-Signaling A Cascade of Kinases, Phosphatases, and Cytokines
Deborah Noble | Jul 4, 1999 | 8 min read
Date: July 5, 1999Table of Cell Signaling Tools At today's research pace, new signaling mechanisms within and between cells are emerging not one by one but in a chain reaction. Each new discovery has strong implications for previously established models, sometimes overturning several assumptions at once. With such a large number of interacting systems--from cell adhesion to differentiation and apoptosis--and receptor pathways, keeping up with the wealth of cell-signaling research tools can be l
Signal Transduction
The Scientist Staff | May 23, 1999 | 5 min read
Edited by: Steve Bunk H. Dudek, S.R. Datta, T.F. Franke, M.J. Birnbaum, R. Yao, G.M. Cooper, R.A. Segal, D.R. Kaplan, M.E. Greenberg, "Regulation of neuronal survival by the serine-threonine protein kinase Akt," Science, 275:661-5, Jan. 31, 1997. (Cited in more than 245 papers since publication) Alex Toker Comments by Henryk Dudek, senior scientist, neurosciences group, Ontogeny Inc., Cambridge, Mass., and Michael E. Greenberg, professor of neurology, Children's Hospital, Harvard Medical Sc
How Cells Find Their Way
Laura Defrancesco | Sep 2, 2001 | 5 min read
Organisms need to sense their environment. By sensing, they can develop, heal wounds, protect against invaders, and create blood vessels. Chemotaxis, or directional sensing, allows cells to detect chemicals with exquisite sensitivity. Some chemotactic cells can sense chemical gradients that differ by only a few percent from a cell's front to its back. Although discovery of the molecule types involved in chemotaxis, as with other kinds of cell signaling events, has mounted, the details of how thi
The Enigmatic Membrane
Muriel Mari, Sharon A. Tooze, and Fulvio Reggiori | Feb 1, 2012 | 10+ min read
Despite years of research, the longstanding mystery of where the autophagosome gets its double lipid bilayers is not much clearer.
Untangling Neuronal Calcium Signaling
Amy Adams | Jan 20, 2002 | 10 min read
From the very moment of conception, calcium plays a pivotal role in fetal development. It rushes in as a wave around the egg to herald the sperm's arrival, binding to proteins that help kick off the whole developmental process. From this first influx, calcium continues to play a critical role in how the body's cells respond to outside signals. Calcium tells muscles to contract and nerves to release neurotransmitters, and is at least part of the signal that helps people form and retain memories.

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