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image: Making CAR T-Cell Therapy Safer

Making CAR T-Cell Therapy Safer

By | April 1, 2017

Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment’s toxicity without sacrificing efficacy.

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Measuring PD-L1 levels was a great start. Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too.

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image: Circadian Rhythms Influence Treatment Effects

Circadian Rhythms Influence Treatment Effects

By | April 1, 2017

Across many diseases, taking medication at specific times of day may make the therapy more effective.

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image: Infographic: Circadian Clock Affects Health and Disease

Infographic: Circadian Clock Affects Health and Disease

By | April 1, 2017

The body's rhythms could affect numerous ailments as well as how people respond to treatments.

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image: Should Healthy People Have Their Exomes Sequenced?

Should Healthy People Have Their Exomes Sequenced?

By | March 24, 2017

With its announced launch of a whole-exome sequencing service for apparently healthy individuals, Ambry Genetics is the latest company to enter this growing market. But whether these services are useful for most people remains up for debate.  

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image: Pathway to Polio Virulence Revealed

Pathway to Polio Virulence Revealed

By | March 23, 2017

Using epidemiological and laboratory data, scientists have mapped out a sequence of mutations through which the attenuated oral polio vaccine reverts to a virulent virus.

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image: Image of the Day: Tubular Origins

Image of the Day: Tubular Origins

By | March 23, 2017

Murine neural tubes, with each image highlighting a different embryonic tissue type (blue). The neural tube itself (left) grows into the brain, spine, and nerves, while the mesoderm (middle) develops into other organs, and the ectoderm (right) forms skin, teeth, and hair.

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image: Inflammation Drives Gut Bacteria Evolution

Inflammation Drives Gut Bacteria Evolution

By | March 16, 2017

Viruses within Salmonella rapidly spread genes throughout the bacterial population during a gut infection, scientists show.

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image: Prominent Epigeneticist Dies

Prominent Epigeneticist Dies

By | March 8, 2017

The National Cancer Institute’s Amar Klar uncovered many of the intricacies of gene silencing and other heritable epigenetic alterations.

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SP140, an epigenetic reader protein mutated in a number of autoimmune disorders, is essential for macrophage function and preventing intestinal inflammation, scientists show. 

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