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Faulty Antibodies Undermine Widespread Research
Faulty Antibodies Undermine Widespread Research
Two papers reveal that many commonly used research antibodies don’t bind as believed, highlighting the need to validate these reagents before use.
Two papers reveal that many commonly used research antibodies don’t bind as believed, highlighting the need to validate these reagents before use.
antibody validation
Opinion: Scientists Need to Demand Better Antibody Validation
Peter S. McPherson | Oct 15, 2019 | 3 min read
My lab has developed a protocol to easily assess the specificity of antibodies—and hopefully stem some of the reproducibility crisis.
Group Proposes Strategies to Improve Antibodies
Kerry Grens | Sep 5, 2016 | 3 min read
An expert committee encourages reagent providers to adopt one of five methods to validate products.
Science Exchange Raises $25M
Kerry Grens | Mar 24, 2016 | 1 min read
With fresh funding, the experiment-services and independent-validation startup will expand its staff.
Exercises for Your Abs
Amber Dance | Feb 1, 2016 | 8 min read
Companies make the antibodies, but it’s up to you to make sure they work in your experiments.
Fighting Back
Mary Beth Aberlin | Feb 1, 2016 | 3 min read
Plants can’t run away from attackers, so they’ve evolved unique immune defenses to protect themselves.
Investigating Irisin
Jenny Rood | Mar 10, 2015 | 2 min read
The discovery of nonspecific antibodies as key components of testing kits used in recent research suggests results touting the discovery of an “exercise hormone” may be invalid, according to a study.
Validating Antibodies: An Urgent Need
Jyoti Madhusoodanan | Dec 1, 2014 | 6 min read
Highlights from a webinar held by The Scientist to discuss the role of antibody validation and cataloging in improving data reproducibility