With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.

A guide to DNA-encoded libraries for drug discovery

By Leonid Moroz The Devolution of Evolution Why evolution and biosystematics courses must be included in all biomedical curricula. Nearly 40 years ago Theodosius Dobzhansky wrote: “Nothing in biology makes sense except in the light of evolution.” How is it, then, that so few newly minted PhDs in the biological sciences have taken any formal graduate school courses in evolution or biodiversity? This fosters a knowledge gap that can become difficult t

Twice yearly, World Health Organization health officials meet to strategize against influenza, a malady that kills at least 250,000 people each year. In a chess match of sorts, they work to predict their opponent's next move, in this case by modifying vaccines to compensate for changes in the critical viral antigen hemagglutinin, which triggers the host's long-term immune memory. It takes several months to manufacture and distribute flu vaccines in sufficient quantities to inoculate vulnerabl

George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.

Jumping genes in bdelloid rotifers are tamped down by DNA methylation performed by an enzyme pilfered from bacteria roughly 60 million years ago, a study finds.

Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.

Researchers aim to unravel the molecular mechanisms by which a single genotype gives rise to diverse castes in eusocial organisms.

A device dubbed the “mother machine” enables real-time observation of mutagenesis in single bacterial cells.