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» somatic mutations

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image: Mosaic Mutations May Not Be Rare

Mosaic Mutations May Not Be Rare

By | June 5, 2015

Somatic mosaicism may be responsible for a larger proportion of genomic variability within humans than previously thought.

2 Comments

image: Personalized Cancer Vaccines

Personalized Cancer Vaccines

By | April 2, 2015

A dendritic cell vaccine targeting melanoma patients’ tumor-specific mutations can activate a broad range of cancer-fighting T cells. 

2 Comments

image: Stem Cell Divisions Help Explain Cancer Risk

Stem Cell Divisions Help Explain Cancer Risk

By | January 1, 2015

An analysis of 31 tissues finds that random mutations acquired during stem cell divisions correlate with lifetime cancer risk—more so than heritable mutations and environmental factors combined.  

7 Comments

image: Mosaic Mutations

Mosaic Mutations

By | July 31, 2014

Some genetic abnormalities that appear to have sprung up independently in children are in fact present in a portion of their parents’ cells.

3 Comments

image: Mutation Patterns Underlie Cancers

Mutation Patterns Underlie Cancers

By | August 15, 2013

More than 20 genome-wide mutational “signatures” account for the vast majority of 30 common cancers.

2 Comments

image: New Type of DNA Discovered?

New Type of DNA Discovered?

By | March 8, 2012

Small circles of extrachromosomal DNA appear to be widespread in mammals, and may be byproducts of small deletions in the nuclear DNA of somatic cells.

3 Comments

image: Deconstructing the Mosaic Brain

Deconstructing the Mosaic Brain

By | August 1, 2011

Sequencing the DNA of individual neurons is a way to dissect the genes underlying major neurological and psychological disorders.

6 Comments

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