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image: Mosaic Mutations May Not Be Rare

Mosaic Mutations May Not Be Rare

By | June 5, 2015

Somatic mosaicism may be responsible for a larger proportion of genomic variability within humans than previously thought.


image: Personalized Cancer Vaccines

Personalized Cancer Vaccines

By | April 2, 2015

A dendritic cell vaccine targeting melanoma patients’ tumor-specific mutations can activate a broad range of cancer-fighting T cells. 


image: Stem Cell Divisions Help Explain Cancer Risk

Stem Cell Divisions Help Explain Cancer Risk

By | January 1, 2015

An analysis of 31 tissues finds that random mutations acquired during stem cell divisions correlate with lifetime cancer risk—more so than heritable mutations and environmental factors combined.  


image: Mosaic Mutations

Mosaic Mutations

By | July 31, 2014

Some genetic abnormalities that appear to have sprung up independently in children are in fact present in a portion of their parents’ cells.


image: Mutation Patterns Underlie Cancers

Mutation Patterns Underlie Cancers

By | August 15, 2013

More than 20 genome-wide mutational “signatures” account for the vast majority of 30 common cancers.


image: New Type of DNA Discovered?

New Type of DNA Discovered?

By | March 8, 2012

Small circles of extrachromosomal DNA appear to be widespread in mammals, and may be byproducts of small deletions in the nuclear DNA of somatic cells.


image: Deconstructing the Mosaic Brain

Deconstructing the Mosaic Brain

By | August 1, 2011

Sequencing the DNA of individual neurons is a way to dissect the genes underlying major neurological and psychological disorders.


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