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image: One Receptor, Two Ligands, Different Responses

One Receptor, Two Ligands, Different Responses

By | August 31, 2016

Host and bacterial ligands that interact with the same cell-surface receptor induce different activities in human macrophages. 

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image: Macrophages Respond to Liver Injury

Macrophages Respond to Liver Injury

By | August 1, 2016

In mice, immune cells from the body cavity surrounding organs arrive at the site of damage to chew up the nuclei of dead cells.

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image: Newly Discovered Emergency Responders to Liver Damage

Newly Discovered Emergency Responders to Liver Damage

By | August 1, 2016

Immune cells called macrophages from the peritoneal cavity of mice migrate to injured livers and aid in repair.

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image: Microglia Tamp Down Neurogenesis

Microglia Tamp Down Neurogenesis

By | April 7, 2016

The immune cells—known for clearing dead cells—also chew up live progenitors in neurogenic regions of mouse brains. 

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image: Adipocyte-Derived DNA Triggers Inflammation

Adipocyte-Derived DNA Triggers Inflammation

By | March 25, 2016

DNA released from dying fat cells stimulates inflammation within murine fat tissue. 

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image: Wiping Out Gut Bugs Stops Obesity

Wiping Out Gut Bugs Stops Obesity

By | November 16, 2015

In mice lacking intestinal microbiota, white fat turns brown and obesity is prevented.

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image: Epigenetics of Trained Innate Immunity

Epigenetics of Trained Innate Immunity

By | September 25, 2014

Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages.

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image: Protein Clumps Spread Inflammation

Protein Clumps Spread Inflammation

By | June 22, 2014

ASC specks—protein aggregations that drive inflammation—are released from dying immune cells, expanding the reach of a defense response.

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image: Activating Beige Fat

Activating Beige Fat

By | June 5, 2014

An innate immune pathway stimulates the activity of heat-producing adipose tissue in mice.

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image: Macrophages Drive Regeneration

Macrophages Drive Regeneration

By | May 22, 2013

The activity of one type of immune cell helps regrow the limbs of amputated salamanders.

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