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In two early trials, vaccines tailored to the mutations in individuals’ cancers appeared to protect 12 of 19 patients against relapse. 

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A new screening tool flags dozens of papers with potential errors.

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The publicly available database found nearly a third of samples included mutations targeted by either approved drugs or therapies in clinical trials. 

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image: Opinion: Token Pharmacovigilance

Opinion: Token Pharmacovigilance

By | May 23, 2017

A US government website for collecting reports of side effects associated with vaccines is broken. Why has no one noticed?

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Sangamo Therapeutics will use zinc finger nucleases to introduce the gene for a missing clotting factor into the livers of men with hemophilia B.

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image: Stem Cell Trial Data Mostly Go Unpublished

Stem Cell Trial Data Mostly Go Unpublished

By | May 5, 2017

Less than half of completed stem cell studies in humans are published in peer-reviewed journals, according to an analysis of regenerative medicine trials. 

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image: Cell Lines Gain Cancer-Related Mutations

Cell Lines Gain Cancer-Related Mutations

By | April 27, 2017

A screen of human embryonic stem cell lines finds several that accumulated changes in the gene TP53, including aberrations commonly seen in cancer.

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image: DNA-Based Zika Vaccine Reaches Phase 2

DNA-Based Zika Vaccine Reaches Phase 2

By | April 4, 2017

An NIAID-sponsored clinical trial advances beyond safety testing.

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At the annual American Association for Cancer Research meeting, researchers discuss the importance of understanding the epigenetic contributors to cancer progression and treatment response.

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image: Rethinking a Cancer Drug Target

Rethinking a Cancer Drug Target

By | March 26, 2017

The results of a CRISPR-Cas9 study suggest that MELK—a protein thought to play a critical role in cancer—is not necessary for cancer cell survival.

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