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clinical trials

FDA Reform to Boost US Economy?
Dan Cossins | Mar 5, 2013 | 2 min read
Two experts propose replacing Phase 3 trials with smaller, faster alternatives and post-market surveillance to invigorate the pharmaceutical industry.
Networking Medicine
Jef Akst | Mar 1, 2013 | 2 min read
Although fully organized patient-run trials are still few and far between, patients are taking a more active role in clinical research.
Speaking of Science
The Scientist | Mar 1, 2013 | 2 min read
March 2013's selection of notable quotes
Do-It-Yourself Medicine
Jef Akst | Mar 1, 2013 | 10+ min read
Patients are sidestepping clinical research and using themselves as guinea pigs to test new treatments for fatal diseases. Will they hurt themselves, or science?
Antibody-Drug Combo Approved
Dan Cossins | Feb 25, 2013 | 2 min read
The FDA approves an antibody-drug conjugate that effectively treats a certain type of advanced breast cancer with fewer side effects than previous drugs.
Stem Cell Trial Nearly Approved
Jef Akst | Feb 15, 2013 | 1 min read
The first human trial of a treatment using induced pluripotent stem cells has received conditional approval from an institutional review board in Japan.
Robo-Eye to Enter US Market
Bob Grant | Feb 11, 2013 | 1 min read
A retinal prosthesis, already available in Europe, can restore partial sight to people with a genetic disorder that causes blindness.
New TB Vaccine Fails Trial
Dan Cossins | Feb 4, 2013 | 2 min read
One of the most advanced tuberculosis vaccines has failed to protect infants from getting the disease in a clinical trial, but it may be effective in adults.
Dung Defeats Drugs
Beth Marie Mole | Jan 18, 2013 | 2 min read
Fecal transplants outcompeted traditional antibiotics at curing a deadly intestinal infection.
Spinning Clinical Trials
Dan Cossins | Jan 16, 2013 | 1 min read
Results of breast cancer drug trials are regularly spun to conceal bias and make the drugs seem more effective or less toxic than they really are.
Researchers Risk Insider Trading
Dan Cossins | Jan 14, 2013 | 2 min read
Academics get paid handsome fees to consult with the financial industry, but run the risk of revealing confidential information that leads to illicit gains.
Failing Alzheimer’s Test?
Beth Marie Mole | Dec 19, 2012 | 2 min read
Two new studies claim that a shoddy test may have caused Alzheimer’s drugs to fail in clinical trials.
Top Science Scandals of 2012
Edyta Zielinska | Dec 17, 2012 | 3 min read
This year’s roundup of bad behavior in the life sciences and new initiatives to prevent misconduct
Chelation Therapy Under Scrutiny
Bob Grant | Nov 15, 2012 | 2 min read
A clinical trial suggesting the heart benefits of the controversial treatment draws criticism from the scientific community.
BioTime Seeks Geron Stem Cell Assets
Vicki Brower | Nov 13, 2012 | 3 min read
Two former Geron CEOs make a bid for the company’s defunct human embryonic stem cell business.
Setback for Malaria Vaccine
Edyta Zielinska | Nov 9, 2012 | 2 min read
The malaria vaccine under development by GSK and the PATH initiative only protects about one in three babies, though some researchers say those odds are better than nothing.
Can Magnesium Magnify Brain Power?
Beth Marie Mole | Oct 28, 2012 | 2 min read
A magnesium supplement thought to improve brain functioning gets a small clinical trial.
Beware of Striking Medical Studies
Dan Cossins | Oct 24, 2012 | 1 min read
A large-scale statistical analysis shows that medical studies revealing “very large effects” seldom stand up when other researchers try to replicate them.
More Questions About IV Drug
Bob Grant | Oct 17, 2012 | 1 min read
Another clinical trial raises concerns about the efficacy and safety of a common intravenous treatment for patients that have lost large amounts of blood.
Uncloaking Clinical Trials
Beth Marie Mole | Oct 16, 2012 | 2 min read
Glaxo­SmithKline will share long-sought, raw trial data—but access will be tightly controlled.  
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