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tag drug development microbiology genetics genomics

Individual bacterial transcriptomes each plotted as a single point create a ring-shaped structure.
Rapidly Dividing Bacteria Coordinate Gene Expression and Replication
Kamal Nahas, PhD | Mar 15, 2024 | 4 min read
E. coli divides faster than it can replicate its genome, while simultaneously expressing its genes. Scientists recently revealed the intricate molecular coordination that makes this possible.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
3D illustration of greenish-brown rod-shaped bacteria.
A Novel Molecule to Tackle Drug-Resistant Bugs
Aparna Nathan, PhD | Feb 12, 2024 | 4 min read
A new antibiotic is the first to block a critical transport mechanism in drug-resistant bacteria.
Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
Punctual Proteins Aid Parasites
Laura Tran, PhD | Feb 1, 2024 | 3 min read
A protein’s timely appearance is crucial for Toxoplasma gondii’s unique replication cycle.
Haydeh Payami is wearing a purple dress and an orange and pink scarf and standing in front of a whiteboard.
A Microbial Link to Parkinson’s Disease
Mariella Bodemeier Loayza Careaga, PhD | Dec 4, 2023 | 6 min read
Haydeh Payami helped uncover the genetic basis of Parkinson’s disease. Now, she hopes to find new ways to treat the disease by studying the gut microbiome.
Setting Standards for Stool
Aparna Nathan, PhD | Jan 19, 2024 | 10+ min read
Microbiome studies have yielded hundreds of ideas for ways to detect and influence human health, but the field struggles with reproducibility challenges that hamper bringing these goals to fruition. Identical tubes of fecal matter should help.
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Understanding Our Enemies: Identifying Mechanisms of Antibiotic Resistance
The Scientist | Aug 3, 2021 | 1 min read
Researchers sample and sequence bacteria from biological and environmental sources to learn how to overcome selective pressure
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
Image shows photorhabdus virulence cassettes (green) binding to insect cells (blue) prior to injection of payload proteins. 
Engineered Bacterial “Syringes” Can Deliver Drugs Into Human Cells
Rohini Subrahmanyam, PhD | Apr 20, 2023 | 4 min read
Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice.

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