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Early exposure to microbes shapes the mammalian immune system by subduing inflammatory T cells.
Replacing immune cells in a mouse model of Rett syndrome, a developmental brain disorder, improved symptoms, suggesting a new target for treatment.
A new bill recently debated in the US Congress seeks to streamline the approval process for drugs.
A new method for transplanting immunologically mismatched organs may remove the need for life-long immunosuppressive drugs to prevent rejection.
Over the past 15 years, new laws and regulations in the United States and the European Union have expanded to require the inclusion of pediatric patients in clinical drug trials. Before these laws were enacted, the US Food and Drug Administration (F
Two key pieces of legislation, enacted to spur drugmakers into testing pharmaceutical products in children, are up for reauthorization in the US Congress this October. Have they done their jobs?
A lot changes in a child’s body over the course of development, and not all changes occur linearly: gene expression can fluctuate, and organs can perform different functions on the way to their final purpose in the body. Here are some of the key deve
The Pediatric Research Equity Act (PREA) of 2003 requires that companies developing new drugs that could be used to treat a condition in children perform clinical trials in kids before winning FDA approval. The Best Pharmaceuticals for Children Act (
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