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image: Failed Drugs Expose Preclinical Blunders

Failed Drugs Expose Preclinical Blunders

By | March 30, 2012

Once a promising cancer treatment, the failure of PARP inhibitors in the clinic may be due to flawed preclinical studies.

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image: Collecting Cancer Data

Collecting Cancer Data

By | March 29, 2012

Two new cancer cell line databases bursting with genomic and drug profiling data may help researchers identify drug targets.

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image: Molecular Blueprints

Molecular Blueprints

By | March 27, 2012

Check out the latest crop of high-resolution structures and how they inform biological function.

2 Comments

image: Let Them Eat Dirt

Let Them Eat Dirt

By | March 22, 2012

Early exposure to microbes shapes the mammalian immune system by subduing inflammatory T cells.

28 Comments

image: Immune Role in Brain Disorder?

Immune Role in Brain Disorder?

By | March 19, 2012

Replacing immune cells in a mouse model of Rett syndrome, a developmental brain disorder, improved symptoms, suggesting a new target for treatment.

2 Comments

image: A FASTer FDA?

A FASTer FDA?

By | March 19, 2012

A new bill recently debated in the US Congress seeks to streamline the approval process for drugs.

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image: Transplant Without Drugs?

Transplant Without Drugs?

By | March 8, 2012

A new method for transplanting immunologically mismatched organs may remove the need for life-long immunosuppressive drugs to prevent rejection.

6 Comments

image: What it Takes to Develop Better Drugs for Kids

What it Takes to Develop Better Drugs for Kids

By | March 1, 2012

Over the past 15 years, new laws and regulations in the United States and the European Union have expanded to require the inclusion of pediatric patients in clinical drug trials.  

2 Comments

image: Are the Kids Alright?

Are the Kids Alright?

By | March 1, 2012

Two key pieces of legislation, enacted to spur drugmakers into testing pharmaceutical products in children, are up for reauthorization in the US Congress this October. Have they done their jobs?

6 Comments

image: How Drugs Interact with a Baby’s Parts

How Drugs Interact with a Baby’s Parts

By | March 1, 2012

A lot changes in a child’s body over the course of development, and not all changes occur linearly: gene expression can fluctuate, and organs can perform different functions on the way to their final purpose in the body. Here are some of the key deve

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