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tag artificial selection immunology developmental biology

Guts and Glory
Anna Azvolinsky | Apr 1, 2016 | 9 min read
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
Maximize In Vitro Culture Possibilities
Linda Raab | Oct 25, 1998 | 4 min read
From Redmond, et al., "Perfused transcapillary smooth muscle and endothelial cell co-culture--a novel in vitro model," In Vitro Cellular & Developmental Biology--Animal, Volume 31:601-609. Copyright 1995 by the Society for In Vitro Biology. Reproduced with permission of the copyright owner. The Cellmax™ culture system uses hollow fiber bioreactor technology in applications as diverse as secreted protein production, lymphocyte expansion, and cellular co-cultivation. The concept of
Why So Soon?
Bob Grant | May 1, 2013 | 10+ min read
Researchers are using modern experimental tools to probe the mysterious molecular pathways that lead to premature labor and birth.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
Notable
Jeffrey Perkel | Jan 6, 2002 | 4 min read
J.A. Camarero et al., "Peptide chemical ligation inside living cells: In vivo generation of a circular protein domain," Bioorganic and Medicinal Chemistry, 9[9]:2479-84, September 2001. F1000 Rating: Recommended "To investigate whether chemo-selective peptide ligations work in vivo, the authors demonstrate the in vivo head-to-tail cyclization of a bioactive SH3 domain using native chemical ligation. The protein precursor was constructed using a clever combination of an intein-fusion protein an
Articles Alert
Simon Silver | Jun 24, 1990 | 7 min read
The Scientist has asked a group of experts to comment periodically upon recent articles that they have found noteworthy. Their selections, presented herein every issue, are neither endorsements of content nor the result of systematic searching. Rather, the list represents personal choices of articles the columnists believe the scientific community as a whole may also find interesting. Reprints of any articles cited here may be ordered through The Genuine Article, 3501 Market St., Philadelphia,
Articles Alert
Simon Silver | Jul 8, 1990 | 7 min read
The Scientist has asked a group of experts to comment periodically upon recent articles that they have found noteworthy. Their selections, presented herein every issue, are neither endorsements of content nor the result of systematic searching. Rather, the list represents personal choices of articles the columnists believe the scientific community as a whole may also find interesting. Reprints of any articles cited here may be ordered through The Genuine Article, 3501 Market St., Philadelphia,
Macrophages Play a Double Role in Cancer
Amanda B. Keener | Apr 1, 2018 | 10+ min read
Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.

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