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tag african american immunology genetics genomics

3D Rendering of Molecular Interaction in CAR Chimeric Antigen Receptor
Next-generation CAR and TCR Cancer Therapies
Danielle Gerhard, PhD | Mar 15, 2024 | 10+ min read
From smart receptors to novel biologics, scientists plan to overcome the challenges of treating solid tumors.
Sickle Cell Treatments Improve; Genetic Cure On The Horizon
Robert Finn | Feb 15, 1998 | 9 min read
WORTH WAITING FOR: Kwaku Ohene-Frempong of the Sickle Cell Disease Association of America says "gene therapy is the ultimate cure of sickle cell disease." Back in 1949, Linus Pauling determined that sickle cell disease-an inherited blood disorder that afflicts 1 in 400 African Americans-is caused by a defect in one of the genes that codes for hemoglobin. Now people with sickle cell disease are finally reaping the benefits of a half-century of research. Within the last two years, several treat
Prospecting for Gold in Genome Gulch
Amy Adams | Apr 14, 2002 | 9 min read
The human genome is much like the American West of the 1850s: Everyone wants a piece of the pie. Similar to gold prospectors of 150 years ago, biotech and pharmaceutical companies, and even universities, are frantically searching for the nuggets of gold that will help them find the mother lode—a gene whose function is sufficiently marketable to make all of the preliminary research worthwhile. Companies that do strike gold get to introduce new classes of drugs to the market. Others hope to
Trickle-Down Genomics: Reforming ""Small Science"" As We Know It
Edward Smith | Jul 18, 1999 | 7 min read
if (n == null) The Scientist - Trickle-Down Genomics: Reforming ""Small Science"" As We Know It The Scientist 13[15]:19, Jul. 19, 1999 Opinion Trickle-Down Genomics: Reforming "Small Science" As We Know It By Edward J. Smith Each generation attempts to develop programs and activities that help it fulfill the ancient Chinese wish "May you live in interesting times." These are indeed interesting times from the perspective of the biologist: The complete geno
Is HIV progression sex-linked?
Bob Grant | Aug 12, 2009 | 3 min read
A genetic variant on the X chromosome may explain why some HIV-infected women are slower to develop full-blown AIDS than men. Although several human genetic variants have been implicated in the control and spread of HIV within a host, this is the first time that a sex chromosome has been found to harbor a suspect stretch of genome related to the disease.HIV-1 budding from cultured lymphocyte Image: C. Goldsmith, courtesy of the Centers for Disease Control and Prevention "I think it's a fasci
Landmarks of Human Variations
Maria Anderson | May 9, 2004 | 5 min read
BUILDING BLOCKS:© 2001 AAASAlong a 106-kilobase stretch of human chromosome 21, one study found that 18 haplotype blocks represent a segment of 147 SNPs from 20 individual copies of the chromosome. One block, containing 26 SNPs and spanning 19 kilobases, is detailed at right. The four most common haplotypes, occurring in 16 of the 20 chromosomes sampled, can be identified by two tag SNPs (bottom right). (Adapted from N. Patil, Science, 294:1719–23, 2001)The myriad medical breakthrough
Bioterrorism Research: New Money, New Anxieties
John Dudley Miller | Apr 6, 2003 | 8 min read
Ned Shaw US scientists have reason to feel both heady and scared. The federal government recently released unprecedented billions of dollars to fund bioterrorism research. Yet, the merits of this sudden shift in focus are being debated, and some worry that the money will be squandered or wasted. "I have been really very upset by the focus on bioterrorism," says Stanley Falkow, professor of microbiology and immunology and of medicine at Stanford University. "Everybody's talking about it, but th
Science Luminaries In Limelight At 1994 Commencement Exercises
Neeraja Sankaran | Jun 26, 1994 | 8 min read
Exercises Author: NEERAJA SANKARAN, pp.1 Date: June 27,1994 Dozens of distinguished science figures have been among the luminaries receiving honorary degrees and offering their words of wisdom to graduating students throughout North America over the past two months. Scientists so honored include Francis S. Collins, director of the National Center for Human Genome Research; Frank Press, former president of the National Academy of S
Science Luminaries In Limelight At 1994 Commencement Exercises
Neeraja Sankaran | Jun 26, 1994 | 8 min read
Exercises Author: NEERAJA SANKARAN, pp.1 Date: June 27,1994 Dozens of distinguished science figures have been among the luminaries receiving honorary degrees and offering their words of wisdom to graduating students throughout North America over the past two months. Scientists so honored include Francis S. Collins, director of the National Center for Human Genome Research; Frank Press, former president of the National Academy of S
Frontlines
Hal Cohen | Apr 14, 2002 | 5 min read
For some children, science is as palatable as brussels sprouts. To elevate the topic in the minds of primary and secondary students, the Franklin Institute of Philadelphia and the Science Museum of London have collaborated to publish an online science gallery entitled "Pieces of Science," www.fi.edu/pieces. The 16 featured objects, from a beginner's guide to genetic engineering to the story of the mold Sir Alexander Fleming discovered and transformed into penicillin has its own its Web page, com

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