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At the annual American Association for Cancer Research meeting, researchers discuss the importance of understanding the epigenetic contributors to cancer progression and treatment response.

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image: CRISPR Screen Detects Functional Gene Regulation

CRISPR Screen Detects Functional Gene Regulation

By | April 3, 2017

A CRISPR-Cas9–based method probes the regulatory roles of noncoding DNA sequences.

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image: Cancer Genomes

Cancer Genomes

By | April 1, 2017

April Scientist to Watch Angela Brooks of the University of California, Santa Cruz, discusses her search to find vulnerabilities buried within the genomes of cancer cells.

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image: Angela Brooks: Splicing Specialist

Angela Brooks: Splicing Specialist

By | April 1, 2017

At the University of California, Santa Cruz, the researcher combs the cancer genome, looking for weaknesses.

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Mice engineered to overproduce the organelles involved in cell division spontaneously develop malignancies.

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image: Gel Scaffolds for Delivery of Immunotherapies

Gel Scaffolds for Delivery of Immunotherapies

By | April 1, 2017

Using biocompatible polymers to carry cancer immune therapies directly to the tumor

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image: Making CAR T-Cell Therapy Safer

Making CAR T-Cell Therapy Safer

By | April 1, 2017

Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment’s toxicity without sacrificing efficacy.

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image: Record-Setting Corn Grows 45 Feet Tall

Record-Setting Corn Grows 45 Feet Tall

By | April 1, 2017

A plant breeder succeeds in growing a huge maize plant thanks to a known mutation and a few environmental tricks.

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image: Neoantigens Enable Personalized Cancer Immunotherapy

Neoantigens Enable Personalized Cancer Immunotherapy

By | April 1, 2017

Tumors’ mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

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image: Starvation Response Triggers Melanoma Invasion

Starvation Response Triggers Melanoma Invasion

By | April 1, 2017

Through similar mechanisms, amino acid depletion in culture and cytokine activity in the tumor microenvironment prompt cancer cells to metastasize.

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