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image: Study Raises Questions About Patient-Derived Xenografts

Study Raises Questions About Patient-Derived Xenografts

By | October 10, 2017

When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds.

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Instructor, Department of Systems Biology, University of Texas MD Anderson Cancer Center. Age: 38

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image: MYC Helps Cancer Hide

MYC Helps Cancer Hide

By | March 10, 2016

The transcriptional regulator dampens the immune system’s ability to elicit an antitumor response, a study shows.

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image: Influential Cancer Biologist Dies

Influential Cancer Biologist Dies

By | August 24, 2015

Chris Marshall, who pieced together a critical signaling pathway involved in cancer, has passed away at age 66.

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image: Book Excerpt from <em>p53</em>

Book Excerpt from p53

By | April 1, 2015

In Chapter 12, "Of Mice and Men," author Sue Armstrong recounts the point at which researchers moved from working with p53 in tissue culture to studying the gene in animal models.

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image: Professional Marksman

Professional Marksman

By | April 1, 2015

Charles Sawyers, who began his research career just as the genetic details of human oncogenes were emerging, codeveloped Gleevec, the quintessential targeted cancer therapy.

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image: Setbacks and Great Leaps

Setbacks and Great Leaps

By | April 1, 2015

The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.

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image: Two-Faced RNAs

Two-Faced RNAs

By | April 1, 2015

The same microRNAs can have opposing roles in cancer.

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image: Resisting Cancer

Resisting Cancer

By | April 1, 2015

If one out of three people develops cancer, that means two others don’t. Understanding why could lead to insights relevant to prevention and treatment.

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image: The Origins of Oversized Chromosomes

The Origins of Oversized Chromosomes

By | November 12, 2014

Researchers reconstruct the formation of the giant neochromosomes that contribute to some cancers.

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