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tag microarray immunology

Roll-Your-Own Microarrays
Jim Kling | Jan 6, 2002 | 3 min read
CDNA microarrays hold great promise for characterizing disease and performing genetic studies, but they're not exactly an out-of-the-box technology just yet. Often the scientists must prepare their own chips. Yet, this process is limited by the amount of space on the array itself—forcing researchers to make choices about which genes to include in their sample. Clinical microarray applications are further limited by the availability of sufficient cell numbers for testing purposes. Illumina
It's all about Cells
Miltenyi Biotec | Jan 12, 2009 | 2 min read
It's all about cells Miltenyi Biotec products and services benefit the biomedical research community worldwide In 1989, a success story began in Bergisch Gladbach near Cologne: MACS® Technology was developed, an efficient and reliable method to tag and separate cells magnetically. Since then, the Miltenyi Biotec team has grown to more than 1,100 employees. They produce and market over 1,400 products for the biomedical research community worldwide,
Bioterrorism Research: New Money, New Anxieties
John Dudley Miller | Apr 6, 2003 | 8 min read
Ned Shaw US scientists have reason to feel both heady and scared. The federal government recently released unprecedented billions of dollars to fund bioterrorism research. Yet, the merits of this sudden shift in focus are being debated, and some worry that the money will be squandered or wasted. "I have been really very upset by the focus on bioterrorism," says Stanley Falkow, professor of microbiology and immunology and of medicine at Stanford University. "Everybody's talking about it, but th
Macro, Mini, Micro
Carina Storrs | Jan 1, 2013 | 7 min read
Clever microfluidic platforms take the study of protein-protein interactions to a new level.
Measuring Cytokine Gene Expression
Josh Roberts(jroberts@the-scientist.com) | Feb 13, 2005 | 6 min read
The immune system is often likened to the military.
Notable
Jeffrey Perkel | Jan 6, 2002 | 4 min read
J.A. Camarero et al., "Peptide chemical ligation inside living cells: In vivo generation of a circular protein domain," Bioorganic and Medicinal Chemistry, 9[9]:2479-84, September 2001. F1000 Rating: Recommended "To investigate whether chemo-selective peptide ligations work in vivo, the authors demonstrate the in vivo head-to-tail cyclization of a bioactive SH3 domain using native chemical ligation. The protein precursor was constructed using a clever combination of an intein-fusion protein an
Distinguishing Th1 and Th2 Cells
Jeffrey Perkel | May 13, 2001 | 10+ min read
Reagents That Distinguish Th1 and Th2 cells Courtesy of R&D SystemsSchematic representation of cytokines influencing the development of antigen-activated naive CD4+ T cells into Th1 and Th2 cells. Editor's note: Although individual techniques are associated with specific researchers in this article, it should be noted that these investigators commonly use several different techniques to analyze T lymphocyte populations. The human body is constantly under siege. It must defend itself fr
Taking The Measure Of The Message
Laura De Francesco | Nov 22, 1998 | 9 min read
Date: November 23, 1998Product Comparison Getting a measure of even a single RNA species has never been easy. Every few years, a new technique comes along--Northerns, ribonuclease protection assays, RT-PCR--that makes the task only incrementally easier. But a quantum leap in technology took place just a few years ago with the introduction of cDNA arrays, and suddenly not just one but hundreds to thousands of target nucleic acids can be analyzed simultaneously and precisely. Since then, array te
Systems Biology: Beyond the Buzz
H. Steven Wiley | Jun 1, 2006 | 10 min read
FEATURESystems Biology © THOM GRAVES Lessons from EGFR research show how to kick-start a systems approach for other areas of biology BY H. STEVEN WILEYARTICLE EXTRASInfographic: Seeing EGFR from a Systems PerspectiveIf you want to start an interesting debate at almost any scientific meeting, just bring up systems biology. Latched onto by the scientific and even
Premade cDNA Libraries
Sarah Goforth | Apr 15, 2001 | 10 min read
Suppliers of Whole-organism cDNA Libraries Suppliers of Tissue-specific cDNA Libraries The questions of gene function, interaction, and regulation are central to the science of molecular biology. Despite the myriad of new technologies, products, and techniques produced by the genomics revolution, some old standards remain just as useful as ever. One such technology is the cDNA (complementary DNA) library. The sheer number of companies offering premade and custom cDNA libraries and products th

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