The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.
High salt concentrations are present in the affected skin of people with atopic dermatitis and promote the differentiation of the T helper cells involved in the development of allergic diseases.
The immunotherapy, which targets CD22 on cancer cells rather than CD19, might prove useful in patients for whom previous T-cell treatments were unsuccessful.