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Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.

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image: Odor, Taste, and Light Receptors in Unusual Locations

Odor, Taste, and Light Receptors in Unusual Locations

By | September 1, 2016

From the gut and airways to the blood, muscle, and skin, diverse sensory receptors are doing unconventional things.

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image: Proprioception: The Sense Within

Proprioception: The Sense Within

By and | September 1, 2016

Knowing where our bodies are in space is critical for the control of our movements and for our sense of self.

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image: What Sensory Receptors Do Outside of Sense Organs

What Sensory Receptors Do Outside of Sense Organs

By | September 1, 2016

Odor, taste, and light receptors are present in many different parts of the body, and they have surprisingly diverse functions.

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image: One Receptor, Two Ligands, Different Responses

One Receptor, Two Ligands, Different Responses

By | August 31, 2016

Host and bacterial ligands that interact with the same cell-surface receptor induce different activities in human macrophages. 

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image: One Antigen Receptor Induces Two T cell Types

One Antigen Receptor Induces Two T cell Types

By | August 26, 2016

Precursor T cells bearing the same antigen receptor adopt two different fates in mice.

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image: Nailing Down HAR Function

Nailing Down HAR Function

By | August 1, 2016

A remaining challenge in the study of human accelerated regions (HARs) is establishing their specific functions during development and other biological processes.

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image: Wanted: Transcriptional Regulators

Wanted: Transcriptional Regulators

By | August 1, 2016

Researchers have designed a screen to find unique molecules, called riboswitches, that determine whether transcription will proceed.

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A 3-D carbon nanotube mesh enables rat spinal tissue sections to reconnect in culture.

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Mismatched ancestral origins of mitochondrial and nuclear DNA boost mouse health.

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