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Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.

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image: Nailing Down HAR Function

Nailing Down HAR Function

By | August 1, 2016

A remaining challenge in the study of human accelerated regions (HARs) is establishing their specific functions during development and other biological processes.

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image: Putting the Pee in Pluripotency

Putting the Pee in Pluripotency

By | April 1, 2016

One man’s waste is another man’s treasure trove of stem cells.

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image: CRISPRi-Controlled Gene Expression

CRISPRi-Controlled Gene Expression

By | March 10, 2016

A variation of the gene-editing technique can more precisely and efficiently downregulate the expression of target genes than traditional CRISPR/Cas9.

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image: Mice Develop with Human Stem Cells

Mice Develop with Human Stem Cells

By | December 21, 2015

Human embryonic stem cells and induced pluripotent stem cells participated normally in early mouse embryo development in a recent study.

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image: CIRM Ups Translational Velocity

CIRM Ups Translational Velocity

By | December 21, 2015

California’s stem cell agency unveiled a 5-year plan that includes starting 50 new clinical trials.

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image: Stem Cell Similarities

Stem Cell Similarities

By | October 28, 2015

Human induced pluripotent stem cells appear functionally equivalent to stem cells from embryos in a study.

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image: Probing Down Syndrome with Mini Brains

Probing Down Syndrome with Mini Brains

By | October 20, 2015

Researchers create cerebral organoids using induced pluripotent stem cells from patient skin cells and characterize protein-expression changes linked to cognitive impairment.

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image: Mini-Kidneys from Stem Cells

Mini-Kidneys from Stem Cells

By | October 7, 2015

Researchers grow kidney-like structures from human induced pluripotent stem cells.

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image: Mitochondria Exchange

Mitochondria Exchange

By | August 26, 2015

A decade of research on intercellular mitochondrial transfer has answered some long-standing questions and raised new ones.

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