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Twisted DNA Increases CRISPR Off-target Effects
Shelby Bradford, PhD | Feb 8, 2024 | 4 min read
Understanding how Cas9 binds off-target sequences can help researchers refine CRISPR-mediated genome editing.
CRISPR Gene Editing: Cas9 and Beyond
Johanna Pruller, PhD and Deanna MacNeil, PhD | Nov 29, 2023 | 7 min read
Researchers create and improve CRISPR-Cas mediated gene editing technologies based on prokaryotic CRISPR systems and eukaryotic DNA repair mechanisms.
Powerful Tool for Genomic Editing
AMSbio | Jun 1, 2014 | 1 min read
CRISPR/Cas9 - A full gene editing tool designed to produce a genetically modified cell using any mammalian cell line and targeting any gene.
Self-Editing Genetic Barcodes
Ruth Williams | Dec 14, 2016 | 3 min read
Scientists create a CRISPR-based, self-editing cellular–barcoding system for extensive molecular recording.
CRISPR Corrects Duchenne-Causing Mutations
Anna Azvolinsky | Apr 12, 2017 | 3 min read
Using CRISPR-Cpf1 gene editing, researchers have fixed mutations that cause a form of muscular dystrophy in cultured human cardiomyocytes and a mouse model.
The Challenge of Using CRISPR to Knock In Genes
Anna Nowogrodzki | Mar 1, 2019 | 7 min read
Researchers are developing an array of techniques for accurately and efficiently inserting genes into DNA.
Researchers Cast Doubt on CRISPR-Like System in Giant Viruses
Tanya Lewis | Jul 7, 2016 | 3 min read
Virologists challenge the hypothesis that mimiviruses possess a nucleic acid defense mechanism.
RNA-Targeting CRISPR
Anna Azvolinsky | Jun 2, 2016 | 3 min read
Scientists identify a novel CRISPR system that zeroes in on single-stranded RNA.
A Selection of CRISPR Proof-of-Principle Studies
Kelly Rae Chi | Mar 1, 2017 | 7 min read
Advice on how to deploy the latest techniques in your own lab
A CRISPR Fore-Cas-t
Carina Storrs | Mar 1, 2014 | 8 min read
A newcomer’s guide to the hottest gene-editing tool on the block