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image: Microbiome Therapy for <em>C. diff</em> Clears Phase 2 Clinical Trial

Microbiome Therapy for C. diff Clears Phase 2 Clinical Trial

By | January 6, 2017

Ribaxamase significantly reduced Clostridium difficile infection in a mid-stage clinical trial involving more than 400 patients.

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image: Antibiotic Assistants

Antibiotic Assistants

By | March 9, 2016

Scientists discover compounds that restore antibiotic efficacy against drug-resistant superbugs.  

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Researchers develop a CRISPR-based, two-phage system that sensitizes resistant bacteria to antibiotics and selectively kills any remaining drug-resistant bugs. 

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image: Virtual Reaction

Virtual Reaction

By | October 20, 2014

A computer simulation could predict antibiotic resistance.

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image: Resistant Wastewater

Resistant Wastewater

By | December 18, 2013

Researchers find an antibiotic resistance gene in wastewater treatment plants in northern China.

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image: Building 3-D Microbial Communities

Building 3-D Microbial Communities

By | October 7, 2013

Researchers apply a 3-D printing technique to structure populations of bacteria in a three-dimensional environment.

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image: Do it Yourself TB Test

Do it Yourself TB Test

By | September 5, 2012

With a cardboard box, a light source, and some filters, roadside clinics can accurately test for tuberculosis.

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Antibiotics share killing mechanism

By | August 31, 2007

Three distinct classes of antibiotics kill bacterial cells with reactive oxygen species

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Interdisciplinary research

By | February 28, 2005

These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.J.F. Roeth et al., "HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail." J Cell Biol, 167:903–13, Dec. 6, 2004.This study defines a novel pathway by which immune evasion protein Nef of HIV-1 traffics MHC-I proteins in T cells from the trans-Golgi network (TGN) to the lysosome for degradation. Indeed, the authors

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How bacteria fight antibiotics

By | August 13, 2004

Researchers report in two separate papers in Science this week on novel methods used by bacteria to avoid being killed by antibiotics. In one study, scientists at the Rockefeller University report that the bacterial cells known as persisters, which tolerate but do not become resistant to antibiotics, preexist in a population and that their random switching between normal and slow-growing persister states enables them to escape antibiotic killing. And in an accompanying paper, Stanford University

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