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From Private to Public

By | January 14, 2010

From Private to Public As head of a unique pharma-academia consortium, Aled Edwards has helped scientists solve the 3D structures of hundreds of disease-related proteins and deposited them in an open access bank—at half the usual cost. By Victoria Stern As an undergraduate at McGill University in Montreal, Aled Edwards spent most of his time playing football and enjoying various intramural sports, like baseball and basketball—and in th

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PAPERS TO WATCH

July 1, 2006

I. Coppens et al.," Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space," Cell , 125:261-74, April 21, 2006. This outstanding paper shows that the intracellular protozoan Toxoplasma gondii exploits host microtubules to recruit and sequester host lysosomes into the parasitophorous vacuole. Through this process, the parasite gains access to host organelles that can provide a source of low-molecular-weight nu

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Dinner, Pets, and Plagues by the Bucketful

By | April 12, 2004

UNEXPECTED ROUTES:Top: Courtesy of Thomas Strömberg; Bottom: Courtesy of David J. Jefferies http://www.ee.surrey.ac.uk/Personal/D.Jefferies/bird/Any time animals are brought together in unnatural densities, it raises the potential for disease disaster. Bullfrogs, mass farmed in South America, are shipped to the United States without disease inspection. Their discarded skins might spread amphibian fungal plagues. Outbreaks of House Finch conjunctivitis and salmonellosis in song birds have sp

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Decoding Cryptosporidium

By | March 29, 2004

Comparatively simple genome reveals why standard antiparasitic drugs have been ineffective

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The Infection Connection in Schizophrenia

By | November 3, 2003

Adapted from image by I.I. Gottesman ©2001  GENES AND MORE: The risks of developing schizophrenia over a lifetime to the relatives of schizophrenia sufferers accord with a largely genetic explanation. Yet with 48% concordance for identical twins, environmental factors may play a role. It's a scary thought that one could develop a debilitating mental illness such as schizophrenia as easily as catching a cold. Well, it's more complicated than that, say advocates of the so-called infec

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Toxoplasma expansion

By | January 17, 2003

flourished after a sudden acquisition of direct oral infectivity.

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Photo: Courtesy of the World Health Organization, P. Virot THE REALITY OF ETHIOPIA: Trying to survive malaria in Ethiopia, on Africa's east coast. In 1998, Ethiopia's infant mortality rate was 116 per 1,000 live births (WHO) compared to 7.2 per 1000 in the US (CDC). Sequencing a 23-megabase genome hardly sounds like a triumph--that's just twice the size of an average yeast genome and one-hundredth of the human genome. Yet, there was cause for celebration after a high-profile team of coll

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How Golgi grows

By | August 1, 2002

New Golgi is derived from autonomous replication from an existing Golgi structure.

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Taming Toxoplasma

By | February 22, 2002

pyrimidine biosynthesis pathway.

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Infection suppresses tumour neovascularization

By | May 10, 2001

blocked neoplastic growth in immunocompromised mice by strong suppression of tumour angiogenesis.

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