© 2005 AAAS
Using a novel bioinformatics approach, researchers identified a gene fusion that seems to occur in a majority of prostate cancers. A common feature of blood cancers, such fusions are rare in solid tumors. A team led by Arul Chinnaiyan at the University of Michigan Medical School found that in 23 of 29 prostate cancer samples, the regulatory region of the
Chinnaiyan's lab had applied cancer outlier profile analysis (COPA) to a subset of microarray data in Oncomine, the group's public database of human cancer gene-expression data. They identified genes with an unusually high degree of overexpression in prostate cancer.
They focused on two genes,
This work "raises the question as to what other solid tumors also have translocation [of these genes]," says Janet Rowley at the University of Chicago Medical Center. Chinnaiyan says he plans to look for causative gene rearrangements in other solid tumors.