Advertisement

Sharing transcription duties

The transcription factors TFIID and SAGA are multi-subunit complexes involved in RNA polymerase II transcription. In the 8 June Nature Lee et al. use oligonucleotide arrays to analyze the relative requirement for the two complexes in yeast (Nature 2000, 405:701-704). Expression of about 70% of yeast genes requires one or more of the subunits shared between TFIID and SAGA, although individual subunits were required to varying extents, and no single subunit was required to the same extent as RNA p

By | June 13, 2000

The transcription factors TFIID and SAGA are multi-subunit complexes involved in RNA polymerase II transcription. In the 8 June Nature Lee et al. use oligonucleotide arrays to analyze the relative requirement for the two complexes in yeast (Nature 2000, 405:701-704). Expression of about 70% of yeast genes requires one or more of the subunits shared between TFIID and SAGA, although individual subunits were required to varying extents, and no single subunit was required to the same extent as RNA polymerase II. The absence of single TFIID-specific and SAGA-specific subunits affects a distinct and generally small subset of genes. A minimum of about 30% of the genome is dependent on TFIID-specific subunits and around 12% of the genome on SAGA-specific subunits.

Advertisement

Follow The Scientist

icon-facebook icon-linkedin icon-twitter icon-vimeo icon-youtube
Advertisement

Stay Connected with The Scientist

  • icon-facebook The Scientist Magazine
  • icon-facebook The Scientist Careers
  • icon-facebook Neuroscience Research Techniques
  • icon-facebook Genetic Research Techniques
  • icon-facebook Cell Culture Techniques
  • icon-facebook Microbiology and Immunology
  • icon-facebook Cancer Research and Technology
  • icon-facebook Stem Cell and Regenerative Science
Advertisement
The Scientist
The Scientist