Recovery from chronic hepatitis C?

Long-term response to chronic hepatitis C treatment suggests complete recovery.

July 6, 2000

New York, July 5, 2000 (Praxis Press) The traditional treatment for chronic hepatitis C combines interferon alfa (3 million units subcutaneously three times a week) with ribavirin (1.0 or 1.2 g daily) for a duration of 6 to 12 months. Studies show that the rate of long-term response is 40 percent 6 months after the end of the treatment but do not document the issue of late relapse in sustained complete responders. In a 12–month follow–up study of patients after therapy, Hélène Fontaine and colleagues found that a virological response six months after discontinuation of the combination treatment is predictive of a 97.8 percent rate of long-term complete response (see paper). The study indicates that a sustained response -- defined as a normal concentration of serum alanine aminotransferase and negative HCV viraemia by PCR 6 months after discontinuation of therapy -- is associated 6 months later with an eradication of HCV RNA and a biochemical normalization and histopathological improvement that strongly suggest complete recovery, since there is no putative genomic integration of HCV RNA.

Popular Now

  1. Unstructured Proteins Help Tardigrades Survive Desiccation
  2. What Budget Cuts Might Mean for US Science
    News Analysis What Budget Cuts Might Mean for US Science

    A look at the historical effects of downsized research funding suggests that the Trump administration’s proposed budget could hit early-career scientists the hardest.  

  3. Inflammation Drives Gut Bacteria Evolution
  4. Women Lose Vision After Stem Cell Treatment
Business Birmingham