Sprue and T cells

NEW YORK, July 17 (Praxis Press) The cellular abnormalities and long-term prognosis of refractory sprue are largely unknown. Cellier and colleagues studied the phenotypic and molecular features of intraepithelial T cells in patients with refractory sprue (see paper). Analysis of intestinal tissue revealed an aberrant intraepithelial lymphoid population and T-cell receptor gene rearrangements in most patients. Patients with aberrant lymphocytes had a poorer prognosis, and some developed overt T-c

July 21, 2000

NEW YORK, July 17 (Praxis Press) The cellular abnormalities and long-term prognosis of refractory sprue are largely unknown. Cellier and colleagues studied the phenotypic and molecular features of intraepithelial T cells in patients with refractory sprue (see paper). Analysis of intestinal tissue revealed an aberrant intraepithelial lymphoid population and T-cell receptor gene rearrangements in most patients. Patients with aberrant lymphocytes had a poorer prognosis, and some developed overt T-cell lymphoma; patients without aberrant lymphocytes made a full recovery. Refractory sprue with aberrant lymphocytes may represent the link between coeliac disease and enteropathy-associated T-cell lymphoma.

Advertisement

Popular Now

  1. Next Generation: Nanotube Scaffolds Reconnect Spinal Neurons
  2. Mapping the Human Connectome
    Daily News Mapping the Human Connectome

    A new map of human cortex combines data from multiple imaging modalities and comprises 180 distinct regions.

  3. Stroke Alters Gut Microbiome, Impacting Recovery
  4. Your Office Has a Distinct Microbiome
RayBiotech