Advertisement

Triple therapy safety

NEW YORK, July 18 (Praxis Press) Multidrug antiretroviral therapy has decreased the morbidity and mortality associated with human immunodeficiency virus (HIV) infection, but the long-term effects and safety of this treatment are unknown. Gulick and colleagues studied the durability and toxicity associated with combined indinavir, zidovudine and lamivudine therapy in HIV-infected patients (see paper). Almost 65% of patients continued therapy for three years. Serum viral loads remained suppressed

July 21, 2000

NEW YORK, July 18 (Praxis Press) Multidrug antiretroviral therapy has decreased the morbidity and mortality associated with human immunodeficiency virus (HIV) infection, but the long-term effects and safety of this treatment are unknown. Gulick and colleagues studied the durability and toxicity associated with combined indinavir, zidovudine and lamivudine therapy in HIV-infected patients (see paper). Almost 65% of patients continued therapy for three years. Serum viral loads remained suppressed and CD4 counts remained elevated relative to baseline values. The main adverse effect was nephrolithiasis. Multidrug antiretroviral therapy can achieve prolonged suppression of HIV viremia.

Advertisement

Popular Now

  1. How Fats Influence the Microbiome
  2. Hearing Help
    Features Hearing Help

    For decades, the only remedies for hearing loss were devices such as hearing aids or cochlear implants. Now, the first pharmaceutical treatments may be on the way.
     

  3. Psychology’s Failure to Replicate
  4. The Great Big Clean-Up
    Features The Great Big Clean-Up

    From tossing out cross-contaminated cell lines to flagging genomic misnomers, a push is on to tidy up biomedical research.

Advertisement
Bina
Bina
Advertisement
Life Technologies