Advertisement

Triple therapy safety

NEW YORK, July 18 (Praxis Press) Multidrug antiretroviral therapy has decreased the morbidity and mortality associated with human immunodeficiency virus (HIV) infection, but the long-term effects and safety of this treatment are unknown. Gulick and colleagues studied the durability and toxicity associated with combined indinavir, zidovudine and lamivudine therapy in HIV-infected patients (see paper). Almost 65% of patients continued therapy for three years. Serum viral loads remained suppressed

July 21, 2000

NEW YORK, July 18 (Praxis Press) Multidrug antiretroviral therapy has decreased the morbidity and mortality associated with human immunodeficiency virus (HIV) infection, but the long-term effects and safety of this treatment are unknown. Gulick and colleagues studied the durability and toxicity associated with combined indinavir, zidovudine and lamivudine therapy in HIV-infected patients (see paper). Almost 65% of patients continued therapy for three years. Serum viral loads remained suppressed and CD4 counts remained elevated relative to baseline values. The main adverse effect was nephrolithiasis. Multidrug antiretroviral therapy can achieve prolonged suppression of HIV viremia.

Advertisement
Advertisement
TECA Corporation
TECA Corporation

Popular Now

  1. Opinion: Too Many Mitochondrial Genome Papers
  2. Antibiotics and the Gut Microbiome
  3. Sex Differences in Pain Pathway
  4. Anti-Vax Doctor Found Dead
    The Nutshell Anti-Vax Doctor Found Dead

    Police are calling the death of James Bradstreet, a physician who claimed vaccines cause autism and offered autism cures to patients, an apparent suicide.

Advertisement
The Scientist