COX-2 and renal function

NEW YORK, July 18 (Praxis Press) A new class of nonsteroidal anti-inflammatory drugs selectively inhibits cyclooxygenase (COX)-2 and may produce fewer adverse effects than nonselective inhibitors. However, animal studies suggest that COX-2 is important for normal renal function.

July 21, 2000

NEW YORK, July 18 (Praxis Press) A new class of nonsteroidal anti-inflammatory drugs selectively inhibits cyclooxygenase (COX)-2 and may produce fewer adverse effects than nonselective inhibitors. However, animal studies suggest that COX-2 is important for normal renal function. Swan and colleagues conducted a randomized, controlled trial of varied doses of rofecoxib (a selective COX-2 inhibitor at therapeutic doses), indomethacin (a COX-1 and COX-2 inhibitor), and placebo in elderly people on a low-sodium diet. Both rofecoxib and indomethacin significantly decreased the patients' glomerular filtration rate. Selective COX-2 inhibitors are also potentially nephrotoxic.

Popular Now

  1. Gut Microbes Linked to Neurodegenerative Disease
  2. Infant Microbiome: Vaginal Delivery Versus C-Section
  3. Top 10 Innovations 2016
    Features Top 10 Innovations 2016

    This year’s list of winners celebrates both large leaps and small (but important) steps in life science technology.

  4. Opinion: WHO’s Silence on Cannabis
Rockland