Breast cancer linked to chromatin remodeling

BRCA1 is a tumor-suppressor gene linked to familial breast and ovarian cancers. In the July 21 Cell, Bochar et al. find that the predominant BRCA1-containing complex in human cells is the SWI/SNF-related chromatin remodeling complex (Cell 2000, 102:257-265). This may explain the multitude of properties that have been ascribed to BRCA1, including effects on transcription, DNA repair, and cell-cycle checkpoints. Mutations in SNF5, another subunit of the SWI/SNF complex, have been shown to result i

By | July 31, 2000

BRCA1 is a tumor-suppressor gene linked to familial breast and ovarian cancers. In the July 21 Cell, Bochar et al. find that the predominant BRCA1-containing complex in human cells is the SWI/SNF-related chromatin remodeling complex (Cell 2000, 102:257-265). This may explain the multitude of properties that have been ascribed to BRCA1, including effects on transcription, DNA repair, and cell-cycle checkpoints. Mutations in SNF5, another subunit of the SWI/SNF complex, have been shown to result in aggressive pediatric cancer, and a close inspection of other SWI/SNF proteins and genes may turn up other cancer culprits.

Advertisement
The Scientist
The Scientist
Advertisement
Roche
Roche

Popular Now

  1. Lost Y Chromosome Genes Found on Autosomes
  2. Brain Drain
    Daily News Brain Drain

    The brain contains lymphatic vessels similar to those found elsewhere in the body, a mouse study shows.

  3. Next Generation: Souped-up Probiotics Pinpoint Cancer
  4. Genomes Point the Way
    Daily News Genomes Point the Way

    Sequence analysis of Egyptian, Ethiopian, and non-African peoples indicates a likely route taken by modern humans migrating out of Africa.

Advertisement
The Scientist
The Scientist
Advertisement
BioTek
BioTek