A baffling protein

BAF, a cellular protein that prevents virus autointegration, may normally function in chromosome condensation.

By | July 31, 2000

Barrier-to-autointegration factor (BAF) is a cellular protein that prevents destructive insertions of retroviruses into their own genomes. In the August 1 Proceedings of the National Academy of Sciences, Zheng et al. propose that BAF's usual function may be in chromosome condensation (Proc. Natl. Acad. Sci. USA 2000, 97:8997-9002). BAF added to DNA forms primarily a dodecamer that binds five or six DNA molecules. The processes of DNA binding and formation of the higher-order BAF multimer are coupled. Interference with BAF function by RNAi in worm embryos results in abnormal chromosome segregation, with chromatin trailing between segregating chromosomes. Thus BAF may function in chromosome organization or condensation.

Popular Now

  1. UC Berkeley Receives CRISPR Patent in Europe
    Daily News UC Berkeley Receives CRISPR Patent in Europe

    The European Patent Office will grant patent rights over the use of CRISPR in all cell types to a University of California team, contrasting with a recent decision in the U.S.

  2. DNA Replication Errors Contribute to Cancer Risk
  3. Should Healthy People Have Their Exomes Sequenced?
    Daily News Should Healthy People Have Their Exomes Sequenced?

    With its announced launch of a whole-exome sequencing service for apparently healthy individuals, Ambry Genetics is the latest company to enter this growing market. But whether these services are useful for most people remains up for debate.  

  4. Rethinking a Cancer Drug Target
    Daily News Rethinking a Cancer Drug Target

    The results of a CRISPR-Cas9 study suggest that MELK—a protein thought to play a critical role in cancer—is not necessary for cancer cell survival.

Business Birmingham