Acute mountain sickness

NEW YORK, July 31 (Praxis Press) Several medications have been used to alleviate or prevent acute mountain sickness (AMS), but their relative efficacies are unknown. Dumont and colleagues reviewed 33 randomized placebo-controlled trials of drugs used to prevent AMS. The mean incidence of AMS above 4,000 meters was 67% in subjects taking a placebo; the rate of ascent correlated with incidence, whereas altitude and mode of ascent did not. Dexamethasone (8-16 mg) and acetazolamide (750 mg) prevente

August 1, 2000

NEW YORK, July 31 (Praxis Press) Several medications have been used to alleviate or prevent acute mountain sickness (AMS), but their relative efficacies are unknown. Dumont and colleagues reviewed 33 randomized placebo-controlled trials of drugs used to prevent AMS. The mean incidence of AMS above 4,000 meters was 67% in subjects taking a placebo; the rate of ascent correlated with incidence, whereas altitude and mode of ascent did not. Dexamethasone (8-16 mg) and acetazolamide (750 mg) prevented AMS (relative risks [RR], 2.50 and 2.18, respectively; number needed to treat, 2.8 and 2.9, respectively). Lower doses of dexamethasone (0.5 or 2 mg) and acetazolamide (500 mg) were ineffective. Dexamethasone was associated with adverse effects upon abrupt discontinuation (RR, 4.45); acetazolamide was associated with parasthesias (RR, 4.02) and polyuria (RR, 4.24). At ascent rates greater than 500 meters/day above 4,000 meters, higher doses of dexamethasone and acetazolamide are equally effective for preventing AMS.

Popular Now

  1. Major German Universities Cancel Elsevier Contracts
  2. Running on Empty
    Features Running on Empty

    Regularly taking breaks from eating—for hours or days—can trigger changes both expected, such as in metabolic dynamics and inflammation, and surprising, as in immune system function and cancer progression.

  3. Most of Human Genome Nonfunctional: Study
  4. Identifying Predatory Publishers
AAAS