Stavudine and liver function

NEW YORK, August 2 (Praxis Press) At least 40 cases of hepatic steatosis and lactic acidosis have been reported in HIV-infected patients taking zidovudine and didanosine, but this syndrome has only rarely been reported in patients taking stavudine. Miller and colleagues reported four cases of hepatic steatosis, lactic acidosis, and myopathy in HIV-infected patients taking stavudine as part of a multidrug antiretroviral regimen. All patients had marked lactic acidosis, elevated levels of alanine

August 3, 2000

NEW YORK, August 2 (Praxis Press) At least 40 cases of hepatic steatosis and lactic acidosis have been reported in HIV-infected patients taking zidovudine and didanosine, but this syndrome has only rarely been reported in patients taking stavudine. Miller and colleagues reported four cases of hepatic steatosis, lactic acidosis, and myopathy in HIV-infected patients taking stavudine as part of a multidrug antiretroviral regimen. All patients had marked lactic acidosis, elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and evidence of fatty liver infiltration on CT scans. Other findings included elevated muscle enzymes, evidence of pancreatitis, biopsy-proven hepatic steatosis, and histologic features suggesting mitochondrial myopathy of muscle. Physicians should routinely monitor ALT and AST levels in patients taking stavudine to detect hepatic steatosis in its early stages.

Popular Now

  1. Decoding the Tripping Brain
  2. Tattoo Ink Nanoparticles Persist in Lymph Nodes
    The Nutshell Tattoo Ink Nanoparticles Persist in Lymph Nodes

    Analysis of the bodies of deceased individuals can’t determine what effect these tattoo remnants have on lymph function, but researchers suggest dirty needles aren’t the only risk of the age-old practice.

  3. Do Microbes Trigger Alzheimer’s Disease?
  4. Metabolomics Data Under Scrutiny
    Daily News Metabolomics Data Under Scrutiny

    Out of 25,000 features originally detected by metabolic profiling of E. coli, fewer than 1,000 represent unique metabolites, a study finds.

AAAS