Abacavir and hypersensitivity

HIV-drug abacavir linked to fatal hypersensitivity reactions.

August 8, 2000

NEW YORK, July 31 (Praxis Press) Ziagen (abacavir) is an oral, guanosine nucleoside reverse transcriptase inhibitor approved for the treatment of HIV infection. Recently the drug's manufacturer, Glaxo Wellcome, notified physicians of cases of fatal hypersensitivity reactions in patients reintroduced the drug. The letter, posted on the US Food and Drug Administration's (FDA) web site, states that, "recent reports indicate that severe or fatal hypersensitivity reactions can occur within hours after Ziagen reintroduction in patients who have no identified history or unrecognized symptoms of hypersensitivity to Ziagen therapy." The letter advises physicians not to reintroduce Ziagen to patients who discontinued the drug because of hypersensitivity. The letter also warns that even if symptoms consistent with hypersensitivity are not identified, reintroduction should be undertaken with caution.

Popular Now

  1. How Plants Evolved Different Ways to Make Caffeine
  2. Thomson Reuters Predicts Nobelists
    The Nutshell Thomson Reuters Predicts Nobelists

    According to citation statistics, researchers behind programmed cell death pathways and CRISPR/Cas9 are among those in line for Nobel Prizes this year.

  3. Sequencing Reveals Genomic Diversity of the Human Brain
  4. Reviewing Results-Free Manuscripts
    The Nutshell Reviewing Results-Free Manuscripts

    An open-access journal is trialing a peer-review process in which reviewers do not have access to the results or discussion sections of submitted papers.

RayBiotech