Childhood abuse and mood disorders

NEW YORK, August 4 (Praxis Press) Childhood abuse may play a role in the development of mood and anxiety disorders but whether the abuse results in a persistent sensitization or hyperactivity of the corticotropin-releasing factor (CRF) systems is unclear. To investigate this relationship, Heim and colleagues, performed a prospective controlled study of 49 healthy women recruited into four study groups: no current major depression and no history of childhood abuse (controls); current major depres

August 8, 2000

NEW YORK, August 4 (Praxis Press) Childhood abuse may play a role in the development of mood and anxiety disorders but whether the abuse results in a persistent sensitization or hyperactivity of the corticotropin-releasing factor (CRF) systems is unclear. To investigate this relationship, Heim and colleagues, performed a prospective controlled study of 49 healthy women recruited into four study groups: no current major depression and no history of childhood abuse (controls); current major depression and history of childhood abuse; no current major depression and history of childhood abuse; current major depression and no history of childhood abuse. The researchers then measured adrenocorticotropic hormone (ACTH), cortisol levels, and heart rate responses to a standardized psychosocial laboratory stressor and compared the responses among the four study groups. They found that women with a history of childhood abuse and a current major depression diagnosis exhibited a more than six-fold greater ACTH response to stress than age-matched controls. Women abused as children may become depressed as a result of hyperactivity of the corticotropin-releasing factor.

Advertisement

Popular Now

  1. NYU Halts Studies, Suspends Investigator
    The Nutshell NYU Halts Studies, Suspends Investigator

    Experiments conducted at the New York University School of Medicine violated several research standards, according to US Food and Drug Administration investigators.

  2. Exercise-Induced Muscle Factor Promotes Memory
  3. The Meaning of Pupil Dilation
    Daily News The Meaning of Pupil Dilation

    Scientists are using pupil measurements to study a wide range of psychological processes and to get a glimpse into the mind.

  4. Brexit’s Effects on Science