A polymerase for sister chromatid cohesion

Cohesins , the proteins that are thought to anchor sister chromatids to one another before anaphase, must be present during DNA replication if cohesion is to be established. In the 4 August Science Wang et al . provide a possible link between replication and cohesion (Science 2000, 289 :774-779). They describe an essential DNA polymerase in budding yeast that both has polymerase activity and is required for sister chromatid cohesion. They suggest that the replication fork m

By | August 10, 2000

Cohesins , the proteins that are thought to anchor sister chromatids to one another before anaphase, must be present during DNA replication if cohesion is to be established. In the 4 August Science Wang et al . provide a possible link between replication and cohesion (Science 2000, 289 :774-779). They describe an essential DNA polymerase in budding yeast that both has polymerase activity and is required for sister chromatid cohesion. They suggest that the replication fork may switch to this polymerase at special cohesion sites, where the polymerase then recruits cohesins.

Popular Now

  1. New Lyme Disease Test Developed by Summer Student
  2. The Neanderthal in the Mirror
    Reading Frames The Neanderthal in the Mirror

    Our evolutionary cousin is no longer a blundering caveman. Recent research has painted a picture of a human ancestor with culture, art, and advanced cognitive skills.

  3. Caloric Restriction Turns White Fat Brown
  4. How to Build Bioinformatic Pipelines Using Galaxy
RayBiotech