HMG-CoA reductase inhibitors

Cancer incidence is lower in patients taking HMG-CoA reductase inhibitors than in patients taking bile acid sequestrants.

August 16, 2000

NEW YORK, August 15 (Praxis Press). Animal studies and some cohort studies in humans have raised concerns about the carcinogenicity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, and the results of clinical trials are inconclusive. Blais and colleagues compared the incidence of cancer in 6,721 patients age 65 years or older taking either HMG-CoA reductase inhibitors or bile acid-binding resins. With a median follow-up of 2.7 years, 542 patients in the cohort developed first malignancies. When compared with patients taking bile acid-binding resins, patients taking HMG-CoA reductase inhibitors were 28% less likely to be diagnosed with any cancers. With the exception of lymphoma, use of HMG-CoA reductase inhibitors was not associated or was inversely associated with the incidence of site-specific cancers. These findings support the safety of HMG-CoA reductase inhibitors and suggest that these drugs may even protect against certain cancers.

Popular Now

  1. Monsanto Buys Rights to CRISPR
    The Nutshell Monsanto Buys Rights to CRISPR

    The US agribusiness secures a global, nonexclusive licensing agreement from the Broad Institute to use the gene-editing technology for agricultural applications.

  2. How Plants Evolved Different Ways to Make Caffeine
  3. ESP on Trial
    Foundations ESP on Trial

    In the 1930s, parapsychologist Joseph Banks Rhine aimed to use scientific methods to confirm the existence of extrasensory perception, but faced criticisms of dubious analyses and irreproducible results.

  4. Another DNA Vaccine for Zika Shows Promise
RayBiotech