Advertisement
Logos Biosystems
Logos Biosystems

Oral insulin

Oral insulin administration does not preserve beta-cell function in patients with newly diagnosed type 1 diabetes.

August 17, 2000

NEW YORK, Aug 14 (Praxis Press) Studies in mice suggest that the oral administration of insulin can modulate immune function and prevent the onset of diabetes. Chaillous and colleagues studied the effects of oral insulin administration on beta-cell function in 131 patients newly diagnosed with autoantibody-positive type 1 diabetes. At 12 months, patients randomized to 2.5 or 7.5 mg of oral insulin or placebo had similar subcutaneous insulin requirements, hemoglobin A1c concentrations, and fasting and stimulated C-peptide concentrations. This pattern was consistent for both juvenile and adult patients and for patients with low and high C-peptide concentrations at enrollment. Further, no significant differences existed in the time course or titers of autoantibodies for the three groups. Doses of 2.5 and 7.5 mg of oral insulin do not preserve beta-cell function in patients with type 1 diabetes during the first year of disease.

Advertisement
Advertisement
Lonza
Lonza

Popular Now

  1. The Mycobiome
    Features The Mycobiome

    The largely overlooked resident fungal community plays a critical role in human health and disease.

  2. Circadian Clock and Aging
    Daily News Circadian Clock and Aging

    Whether a critical circadian clock gene is deleted before or after birth impacts the observed aging-related effects in mice.

  3. Biologist Resigns Amid Sexual Misconduct Probe
  4. Turning Tumor Cells Against Cancer
Advertisement
PDA
PDA
Advertisement
Life Technologies