Advertisement

Many ways to make a breast tumor

In the 17 August Nature Perou et al. present a DNA microarray analysis of 65 human breast tumor specimens from 42 different individuals (Nature 2000, 406:747-752). Of the 8,102 genes analyzed, 1,753 varied in abundance at least fourfold in at least three samples. These genes could be clustered into groups that correlated with mitotic index, regulation of the interferon pathway, and the relative abundance of endothelial cells, stromal cells, adipose cells, B or T cells and macrophages. Expression

By | August 21, 2000

In the 17 August Nature Perou et al. present a DNA microarray analysis of 65 human breast tumor specimens from 42 different individuals (Nature 2000, 406:747-752). Of the 8,102 genes analyzed, 1,753 varied in abundance at least fourfold in at least three samples. These genes could be clustered into groups that correlated with mitotic index, regulation of the interferon pathway, and the relative abundance of endothelial cells, stromal cells, adipose cells, B or T cells and macrophages. Expression patterns derived from a single patient at different times were usually very similar, but analysis of all the samples emphasized the number of different ways that a breast tumor can develop. Nevertheless, the samples could be subdivided into certain groups; a report correlating these groupings with clinical data will appear elsewhere.

Advertisement
Keystone Symposia
Keystone Symposia

Follow The Scientist

icon-facebook icon-linkedin icon-twitter icon-vimeo icon-youtube
Advertisement

Stay Connected with The Scientist

  • icon-facebook The Scientist Magazine
  • icon-facebook The Scientist Careers
  • icon-facebook Neuroscience Research Techniques
  • icon-facebook Genetic Research Techniques
  • icon-facebook Cell Culture Techniques
  • icon-facebook Microbiology and Immunology
  • icon-facebook Cancer Research and Technology
  • icon-facebook Stem Cell and Regenerative Science
Advertisement
Enzo Life Sciences
Enzo Life Sciences
Advertisement
The Scientist
The Scientist