Estrogen and CHD

NEW YORK, August 25 (Praxis Press). Although coronary heart disease (CHD) is a major cause of illness and death in women, the role of estrogen in its treatment and prevention remains unclear. To examine this relationship, Herrington and colleagues randomized a total of 309 women with angiographically verified CHD to receive: 0.625 mg of conjugated estrogen per day; 0.625 mg of conjugated estrogen plus 2.5 mg of medroxyprogesterone acetate per day; or a placebo. They then followed the women for a

August 25, 2000

NEW YORK, August 25 (Praxis Press). Although coronary heart disease (CHD) is a major cause of illness and death in women, the role of estrogen in its treatment and prevention remains unclear. To examine this relationship, Herrington and colleagues randomized a total of 309 women with angiographically verified CHD to receive: 0.625 mg of conjugated estrogen per day; 0.625 mg of conjugated estrogen plus 2.5 mg of medroxyprogesterone acetate per day; or a placebo. They then followed the women for approximately three years, analyzing baseline and follow-up coronary angiograms using quantitative methods. They found that estrogen and estrogen plus medroxyprogesterone acetate produced significant reductions in low-density lipoprotein cholesterol levels and significant increases in high-density lipoprotein cholesterol levels; however, neither treatment altered the progression of coronary atherosclerosis. These results suggest that estrogen replacement will not provide cardiovascular benefit to women with established CHD, at least in the short term.

Popular Now

  1. Exercise Boosts Telomere Transcription
  2. Classic Example of Symbiosis Revised
  3. The Genetic Components of Rare Diseases
  4. Orangutan Imitates Human Speech
RayBiotech