Advertisement
NeuroScientistNews
NeuroScientistNews

Sequence of a big bug

, the bug responsible for most cystic fibrosis deaths, reveals lots of pumps and lots of regulation.

By | September 4, 2000

The 6.3 Mbp sequence of Pseudomonas aeruginosa, the bug responsible for most cystic fibrosis deaths, reveals lots of pumps and lots of regulation. As reported in the 31 August Nature, this, the largest bacterial genome sequenced thus far, is available thanks to an effort that used the shotgun sequencing capabilities of the University of Washington in Seattle and funding provided by the Cystic Fibrosis Foundation and Pathogenesis Corporation (Stover et al., Nature 2000, 406:959-964). The Foundation's next effort will be to make P. aeruginosa arrays available at a reasonable cost. With 5,570 predicted genes, P. aeruginosa has almost as many genes as budding yeast. This complexity is particularly apparent in regulation: a full 8-10% of the genes encode proteins with sequences similar to known regulators of gene expression. This may explain the bacteria's ability to live just about anywhere on just about anything. The sequence also unveiled a reason why P. aeruginosa is so troublesome for cystic fibrosis patients. The bacterium has six additional 'RND' multi-drug efflux pumps to add to the four that were already known.

Advertisement

Follow The Scientist

icon-facebook icon-linkedin icon-twitter icon-vimeo icon-youtube
Advertisement
NeuroScientistNews
NeuroScientistNews

Stay Connected with The Scientist

  • icon-facebook The Scientist Magazine
  • icon-facebook The Scientist Careers
  • icon-facebook Neuroscience Research Techniques
  • icon-facebook Genetic Research Techniques
  • icon-facebook Cell Culture Techniques
  • icon-facebook Microbiology and Immunology
  • icon-facebook Cancer Research and Technology
  • icon-facebook Stem Cell and Regenerative Science
Advertisement
The Scientist
The Scientist
Advertisement
NeuroScientistNews
NeuroScientistNews
Life Technologies